89597-80-8Relevant articles and documents
Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1
Zhang, Zhongsheng,Ojo, Kayode K.,Johnson, Steven M.,Larson, Eric T.,He, Penqing,Geiger, Jennifer A.,Castellanos-Gonzalez, Alejandro,White Jr., A. Clinton,Parsons, Marilyn,Merritt, Ethan A.,Maly, Dustin J.,Verlinde, Christophe L.M.J.,Van Voorhis, Wesley C.,Fan, Erkang
scheme or table, p. 5264 - 5267 (2012/09/07)
Calcium-dependent protein kinase-1 (CDPK1) from Cryptosporidium parvum (CpCDPK1) and Toxoplasma gondii (TgCDPK1) have become attractive targets for discovering selective inhibitors to combat infections caused by these protozoa. We used structure-based design to improve a series of benzoylbenzimidazole-based compounds in terms of solubility, selectivity, and potency against CpCDPK1 and TgCDPK1. The best inhibitors show inhibitory potencies below 50 nM and selectivity well above 200-fold over two human kinases with small gatekeeper residues.
