896-80-0

Basic information

• Product Name: Sulfone, 2,4-dinitrophenyl phenyl
• Synonyms: Sulfone, 2,4-dinitrophenyl phenyl;2,4-Dinitro[sulfonylbisbenzene];2,4-Dinitrophenylphenyl sulfone;(4-Nitrophenyl)(2-nitrophenyl) sulfone;2-Nitrophenyl 4-nitrophenyl sulfone
• CAS NO: 896-80-0
• Molecular Formula: C₁₂H₈N₂O₆S
• Molecular Weight: 0
• Mol File: 896-80-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 519.9°C at 760 mmHg
• Flash Point: 268.2°C
• Appearance: /
• Density: 1.53g/cm³
• Vapor Pressure: 2.15E-10mmHg at 25°C
• Refractive Index: 1.637
• CAS DataBase Reference: Sulfone, 2,4-dinitrophenyl phenyl(CAS DataBase Reference)
• NIST Chemistry Reference: Sulfone, 2,4-dinitrophenyl phenyl(896-80-0)
• EPA Substance Registry System: Sulfone, 2,4-dinitrophenyl phenyl(896-80-0)

Safety Data

• Hazardous Substances Data: 896-80-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H8N2O6S/c15-13(16)9-6-7-12(11(8-9)14(17)18)21(19,20)10-4-2-1-3-5-10/h1-8H

Upstream product

• 2486-09-1 2,4-dinitro-1-phenylsulfanyl-benzene 
• 742-25-6 2,4-dinitrophenyl 4-methylbenzenesulfonate 
• 873-55-2 sodium benzenesulfonate 
• 97-00-7 1-chloro-2,4-dinitro-benzene 
• 618-41-7 Benzenesulfinic acid 
• 899-03-6 (4-chloro-phenyl)-(2,4-dinitro-phenyl)-sulfone 
• 98-09-9 benzenesulfonyl chloride 
• 3111-52-2 potassium thiophenolate 
• 108-98-5 thiophenol 

Downstream Products

• 839-93-0 1-(2,4-dinitrophenyl)piperidine 
• 899-02-5 (2,4-dinitro-phenyl)-p-tolyl sulfone 
• 672288-78-7 1-benzenesulfonyl-4-methoxy-2-nitro-benzene 
• 70415-93-9 1,4-bis-benzenesulfonyl-2-nitro-benzene 
• 116435-84-8 4-benzenesulfonyl-m-phenylenediamine 
• 618-41-7 Benzenesulfinic acid 
• 14314-69-3 potassium 2,4-dinitrophenolate 
• 26652-46-0 potassium benzenesulfinate 
• 71466-62-1 1-(1-Adamantyl)-4-phenylsulfonyl-3-nitrobenzol 
• 25775-97-7 2,4-dinitrophenyl β-D-glucopyranoside 
• 77516-85-9 1-O-(2,4-dinitrophenyl)-2,3,4,6-tetra-O-benzyl-β-D-glucopyranoside 
• 17042-32-9 1-O-(2,4-dinitrophenyl)-2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside 
• 39242-76-7 4-(2,4-dinitrophenyl)morpholine 
• 119-27-7 2,4-dinitroanisole 

Relevant articles and documents

Synthesis and biological evaluation of optimized inhibitors of the mitotic kinesin Kif18A

The mitotic spindle, a highly dynamic structure composed of microtubules, mediates the segregation of the previously duplicated genome into the two nascent daughter cells. Errors in this process contribute to pathology including tumor formation. Key for the shape and function of the mitotic spindle are kinesins, molecular motor proteins that convert chemical energy into mechanical work. Due to their fast mode of action, small molecules are valuable tools to dissect the dynamic functions of kinesins during mitosis. In this study, we report the identification of optimized small molecule inhibitors of the mitotic kinesin Kif18A. Using BTB-1, the first identified Kif18A inhibitor, as a lead compound, we synthesized a collection of derivatives. We demonstrate that some of the synthesized derivatives potently inhibited the ATPase activity of Kif18A with a half maximal inhibitory concentration (IC50) value in the low micromolar range. In vitro analysis of a panel of Kif18A-related kinesins revealed that the two most potent compounds show improved selectivity compared to BTB-1. Structure-activity relationship studies identified substituents mediating undesired inhibitory effects on microtubule polymerization. In summary, our study provides key insights into the mechanism of action of BTB-1 and its analogs, which will have a great impact on the further development of highly selective and bioactive Kif18A inhibitors. Since Kif18A is frequently overexpressed in solid tumors, such compounds are not only of great interest for basic research but also have the potential to open up new strategies for the treatment of human diseases.

INFLUENCE OF SUBSTITUENTS ON THE FREQUENCY OF STRETCHING VIBRATIONS OF SULFUR-CONTAINING BRIDGING GROUPS IN DIPHENYL SYSTEMS

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VARIATION OF THE VALENCE OF SULFUR IN SUBSTITUTED 2,4-DINITROPHENYL PHENYL SULFOXIDES IN REARRANGEMENT PROCESSES

The oxidation of the bridging sulfur atom in diphenyl sulfides, leading to the formation of sulfoxides and sulfones, was investigated.The various rearrangement processes which occur in substituted 2,4-dinitrophenyl phenyl sulfoxides during electron impact and lead to the appearance of characteristic fragment ions were demonstrated.The effect of the nature of substituents on the main directions in mass-spectrometric dissociation was investigated, and a correlation was obtained between log Z'/Z for the fragment due to elimination of the bridging SO group from the molecular ion and the Hammett ? constants.