897046-42-3

Basic information

• Product Name: 1-Tert-butyl2-Methyl4-hydroxypyrrolidine-1,2-dicarboxylate
• Synonyms: 4-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) 2-methyl ester;tert-Butoxycarbonyl-DL-4-hydroxyproline methyl ester
• CAS NO: 897046-42-3
• Molecular Formula: C₁₁H₁₉NO₅
• Molecular Weight: 245.27226
• Mol File: 897046-42-3.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Tert-butyl2-Methyl4-hydroxypyrrolidine-1,2-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Tert-butyl2-Methyl4-hydroxypyrrolidine-1,2-dicarboxylate(897046-42-3)
• EPA Substance Registry System: 1-Tert-butyl2-Methyl4-hydroxypyrrolidine-1,2-dicarboxylate(897046-42-3)

Safety Data

• Hazardous Substances Data: 897046-42-3(Hazardous Substances Data)

Usage

Chemical Class

Pyrrolidine carboxylates

Physical Appearance

White to off-white crystalline powder

Usage

Synthesis of pharmaceuticals and agrochemicals

Potential as Chiral Intermediate

In drug synthesis (e.g., Enalapril for hypertension and heart failure)

Reagent in Organic Synthesis

For determining enantiomeric purity using nuclear magnetic resonance spectroscopy as a chiral shift reagent

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 51-35-4 3-hydroxy-dl-proline 
• 67-64-1 acetone 
• 186581-53-3 diazomethane 
• 1157846-03-1 cis-4-hydroxy-N-tert-butoxycarbonyl-D-proline 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 84520-67-2 (2S,4R)-4-(methylsulfonyloxy)pyrrolidine-1,2-dicarboxylic acid 1-tert-butylester-2-methylester 
• 156865-72-4 tert-butyl 4-hydroxy-2-methylpyrrolidine-1-carboxylate 
• 362706-25-0 tert-butyl 2-methyl-4-oxopyrrolidine-1-carboxylate 
• 1584148-14-0 N-((R)-1-(3-chlorophenyl)ethyl)-5-methyl-2-((tetrahydro-2H-pyran-4-yl)amino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide 
• 1188543-32-9 4-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxymethyl]-1-(3-trifluoromethyl-benzyl)-pyrrolidine-2-carboxylic acid methyl ester 
• 1188543-30-7 4-{4-[2,6-dioxo-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-2,3,6,7-tetrahydro-1H-purin-8-yl]-phenoxymethyl}-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 

Relevant articles and documents

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