89784-02-1

Basic information

• Product Name: 2-AMINO-4-CHLORO-6-ETHOXYPYRIMIDINE
• Synonyms: 4-CHLORO-6-ETHOXY-2-PYRIMIDINAMINE;2-AMINO-4-CHLORO-6-ETHOXYPYRIMIDINE;4-Chloro-6-ethoxypyrimidin-2-amine;4-ethoxy-6-chloro-pyrimidin-2-ylamine;4-Chloro-6-ethoxy-pyrimidin-2-ylamine
• CAS NO: 89784-02-1
• Molecular Formula: C₆H₈ClN₃O
• Molecular Weight: 173.6
• Mol File: 89784-02-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 352.6 °C at 760 mmHg
• Flash Point: 167 °C
• Appearance: /
• Density: 1.329 g/cm³
• Vapor Pressure: 3.81E-05mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-AMINO-4-CHLORO-6-ETHOXYPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4-CHLORO-6-ETHOXYPYRIMIDINE(89784-02-1)
• EPA Substance Registry System: 2-AMINO-4-CHLORO-6-ETHOXYPYRIMIDINE(89784-02-1)

Safety Data

• Hazardous Substances Data: 89784-02-1(Hazardous Substances Data)

Usage

General Description

2-AMINO-4-CHLORO-6-ETHOXYPYRIMIDINE, also known as acephate, is an organophosphate insecticide and acaricide used to control a wide range of pests on crops such as cotton, soybeans, and tobacco. It acts as a cholinesterase inhibitor, disrupting the nervous system of insects and mites, ultimately causing paralysis and death. This chemical is soluble in water and has a low potential for bioaccumulation in aquatic organisms. Acephate is relatively non-toxic to birds and does not persist in the environment, making it a popular choice for pest control in agriculture. However, it is important to handle and apply this chemical with caution, as it can be harmful to humans and other mammals if exposure occurs.

InChI:InChI=1/C6H8ClN3O/c1-2-11-5-3-4(7)9-6(8)10-5/h3H,2H2,1H3,(H2,8,9,10)

Upstream product

• 56-05-3 2-Amino-4,6-dichloropyrimidine 
• 64-17-5 ethanol 
• 141-52-6 sodium ethanolate 

Downstream Products

• 1018450-70-8 C₁₆H₁₅Cl₃N₄O₃S 

Relevant articles and documents

Development of the Late-Phase Manufacturing Process of ZPL389: Control of Process Impurities by Enhanced Process Knowledge

The development of the late-phase manufacturing process of the drug candidate ZPL389 and the strategies for the control of impurities are outlined in detail. Selective salt formation at several stages was pivotal to controlling the process impurities. The extensive optimization of the N-methylation of a Boc-protected amine with dimethyl sulfate and of a nucleophilic aromatic substitution without the use of metal catalysts led to a robust, scalable process. The process was demonstrated on a >100 kg scale. Overall, improved drug substance quality, higher yield, and reduction of the process mass intensity were achieved.