898269-36-8Relevant articles and documents
Highly antiproliferative, low-calcemic, side-chain amide and hydroxamate analogs of the hormone 1α,25-dihydroxyvitamin D3
Sinishtaj, Sandra,Jeon, Heung Bae,Dolan, Patrick,Kensler, Thomas W.,Posner, Gary H.
, p. 6341 - 6348 (2007/10/03)
Four new side-chain amide (2 and 3) and hydroxamate (4 and 5) analogs of the hormone calcitriol (1) have been prepared. Even though lacking the 25-OH group characteristic of natural calcitriol (1), analogs 2-4 are as antiproliferative in vitro as calcitriol (1) but are 20-40 times less calciuric in vivo than calcitriol (1).