898559-18-7

Basic information

• Product Name: (S)-ethyl 2-acetamido-3-(4-chlorophenyl)propanoate
• Synonyms: (S)-ethyl 2-acetamido-3-(4-chlorophenyl)propanoate
• CAS NO: 898559-18-7
• Molecular Weight: 269.728
• Mol File: 898559-18-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (S)-ethyl 2-acetamido-3-(4-chlorophenyl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-ethyl 2-acetamido-3-(4-chlorophenyl)propanoate(898559-18-7)
• EPA Substance Registry System: (S)-ethyl 2-acetamido-3-(4-chlorophenyl)propanoate(898559-18-7)

Safety Data

• Hazardous Substances Data: 898559-18-7(Hazardous Substances Data)

Upstream product

• 132165-55-0 C₁₃H₁₄ClNO₃ 
• 64-17-5 ethanol 
• 14091-10-2 (S)-2-acetamido-3-(4-chlorophenyl)propanoic acid 
• 132165-55-0 ethyl (Z)-2-acetylamino-3-(4-chlorophenyl)-2-propenoate 

Relevant articles and documents

Chiral 1,2,3,4-tetrahydro-1-naphthylamine-derived phosphine-phosphoramidite ligand (THNAPhos): Application in highly enantioselective hydrogenations of functionalized C=C bonds

We have recently reported a new chiral 1,2,3,4-tetrahydro-1-naphthylamine- derived phosphine-phosphoramidite ligand, (Rc,Ra)- THNAPhos, that is highly efficient in the rhodium-catalyzed asymmetrichydrog enation of a broad range of aenol ester phosphonates. To further demonstrate the utility of THNAPhos in asymmetric hydrogenation, in this paper, we describe its new application in the asymmetrichy drogenation of α-dehydroamino acid esters, enamides, dimethyl itaconate and α-enamido phosphonates. The results disclosed that the Rh/(Rc,Ra)-THNAPhos complex is highly effective for the enantioselective hydrogenation of these kinds of functionalized C=C olefins, affording the corresponding hydrogenation product in excellent enantioselectivities (normally over 99% ee).

Resolution of N-protected amino acid esters using whole cells of Candida parapsilosis ATCC 7330

Whole cells of Candida parapsilosis ATCC 7330 were used for the resolution of N-acetyl amino acid esters. Excellent enantioselectivities (E = 40 to >500) were achieved for the resolution of N-protected protein and non-protein amino acid esters giving good yields (28-50%) and high enantiomeric excesses (up to >99%) for both enantiomers.