898767-04-9

Basic information

• Product Name: 3-CHLORO-1-(2-FLUOROPHENYL)-1-OXOPROPANE
• Synonyms: 3-CHLORO-1-(2-FLUOROPHENYL)-1-OXOPROPANE;3-Chloro-1-(2-fluorophenyl)propan-1-one;3-Chloro-1-(2-fluorophenyl)-1-propanone
• CAS NO: 898767-04-9
• Molecular Formula: C₉H₈ClFO
• Molecular Weight: 186.61
• Mol File: 898767-04-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 265°C at 760 mmHg
• Flash Point: 114.1°C
• Appearance: /
• Density: 1.219g/cm³
• Vapor Pressure: 0.00937mmHg at 25°C
• Refractive Index: 1.509
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 3-CHLORO-1-(2-FLUOROPHENYL)-1-OXOPROPANE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-1-(2-FLUOROPHENYL)-1-OXOPROPANE(898767-04-9)
• EPA Substance Registry System: 3-CHLORO-1-(2-FLUOROPHENYL)-1-OXOPROPANE(898767-04-9)

Safety Data

• Hazardous Substances Data: 898767-04-9(Hazardous Substances Data)

Usage

General Description

3-CHLORO-1-(2-FLUOROPHENYL)-1-OXOPROPANE, also known as 3-chloro-1-(2-fluorophenyl)-1-propanone, is a chemical compound with the molecular formula C9H7ClF. It is a ketone derivative with a chlorine atom at the 3-position and a fluorophenyl group at the 1-position. 3-CHLORO-1-(2-FLUOROPHENYL)-1-OXOPROPANE is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of various biologically active compounds. It is also utilized in the production of agrochemicals and other specialty chemicals. 3-CHLORO-1-(2-FLUOROPHENYL)-1-OXOPROPANE is a colorless to pale yellow liquid with a strong odor, and it should be handled with care due to its potential hazards.

InChI:InChI=1/C9H8ClFO/c10-6-5-9(12)7-3-1-2-4-8(7)11/h1-4H,5-6H2

Upstream product

• 74-85-1 ethene 
• 393-52-2 2-Fluorobenzoyl chloride 
• 445-29-4 o-fluoro-benzoic acid 
• 1072-85-1 o-fluorobromobenzene 
• 625-36-5 2-chloropropionyl chloride 

Downstream Products

• 651735-59-0 7-fluoro-2,3-dihydro-1H-inden-1-one 
• 1114086-21-3 (R)-6-allyl-3-((S)-1-(4'-fluoro-[1,1'-biphenyl]-4-yl)ethyl)-6-(2-fluorophenyl)-1,3-oxazinan-2-one 
• 1114086-08-6 (R)-3-((S)-1-(4'-fluorobiphenyl-4-yl)ethyl)-6-(2-fluorophenyl)-6-(3-hydroxypropyl)-1,3-oxazinan-2-one 
• 1114086-18-8 (R)-6-allyl-3-((S)-1-(4-bromophenyl)ethyl)-6-(2-fluorophenyl)-1,3-oxazinan-2-one 

Relevant articles and documents

ISOXAZOLIDINE DERIVED INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE 1 (RIPK 1)

The present disclosure relates generally to methods and compositions for preventing or arresting cell death and/or inflammation.

A Convenient Synthesis of 7-Halo-1-indanones and 8-Halo-1-tetralones

A regioselective oxidation of N-indan-4-yl-acetamide or N-(5,6,7,8-tetrahydronaphthalen-1-yl)acetamide with potassium permanganate followed by acidic hydrolysis gave 7-aminoindan-1-one or 8-aminotetral-1-one in good yield. The amino ketones were converted to the corresponding 7-haloindanone or the 8-halotetralone. Another method to prepare 7-haloindan-1-ones was completed by a cyclization of 3-chloro-1-(2-halophenyl)propan-1-one under Friedel-Crafts conditions to produce the product in gram quantity.