898776-62-0

Basic information

• Product Name: ETHYL 4-(2-OXO-2-PHENYLETHYL)BENZOATE
• Synonyms: ETHYL 4-(2-OXO-2-PHENYLETHYL)BENZOATE
• CAS NO: 898776-62-0
• Molecular Formula: C₁₇H₁₆O₃
• Molecular Weight: 268.31
• Mol File: 898776-62-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 411.9°C at 760 mmHg
• Flash Point: 182.1°C
• Appearance: /
• Density: 1.136g/cm³
• Vapor Pressure: 5.38E-07mmHg at 25°C
• Refractive Index: 1.567
• CAS DataBase Reference: ETHYL 4-(2-OXO-2-PHENYLETHYL)BENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-(2-OXO-2-PHENYLETHYL)BENZOATE(898776-62-0)
• EPA Substance Registry System: ETHYL 4-(2-OXO-2-PHENYLETHYL)BENZOATE(898776-62-0)

Safety Data

• Hazardous Substances Data: 898776-62-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C17H16O3/c1-2-20-17(19)15-10-8-13(9-11-15)12-16(18)14-6-4-3-5-7-14/h3-11H,2,12H2,1H3

Upstream product

• 64-17-5 ethanol 
• 346623-13-0 α'-oxo-bibenzyl-4-carboxylic acid 
• 455-14-1 4-trifluoromethylphenylamine 
• 30934-71-5 1-(1,2-Dibromo-2-phenyl-ethyl)-4-trifluoromethyl-benzene 
• 370-99-0 4-trifluoromethyldiphenylethyne 
• 1149-56-0 1-styryl-4-(trifluoromethyl)benzene 
• 30934-68-0 1-phenyl-2-(4-(trifluoromethyl)phenyl)ethan-1-one 
• 621-82-9 Cinnamic acid 
• 5462-71-5 4-cyanophenylacetic acid 
• 59824-23-6 4-(2-oxo-2-phenylethyl)benzonitrile 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 93-91-4 1-phenylbutan-1,3-dione 
• 98-86-2 acetophenone 
• 98-88-4 benzoyl chloride 

Downstream Products

• 855469-68-0 4-(1-benzoyl-propyl)-benzoic acid 
• 1286715-77-2 C₂₀H₂₁NO₃ 
• 1333378-05-4 ethyl 4-(1,4-dioxo-1,4-diphenyl-3-p-tolylbutan-2-yl)benzoate 
• 5925-68-8 (S)-methyl thiobenzoate 
• 1387574-31-3 ethyl 4-[2-(2-thienyl)-2-oxoethyl]benzoate 
• 1387574-30-2 ethyl 4-[2-[4-(1,1-dimethylethyl)phenyl]-2-oxoethyl]benzoate 
• 1387574-34-6 ethyl 4-(2-oxodecyl)benzoate 
• 93-99-2 benzoic acid phenyl ester 
• 1593235-32-5 4-(2-benzoxazolylmethyl)benzoic acid ethyl ester 

Relevant articles and documents

Versatile and base-free copper-catalyzed α-arylations of aromatic ketones using diaryliodonium salts

A ligand and base-free copper catalyzed synthetic method for the efficient α-arylation of aromatic ketones is described. In order to avoid strong bases, ketone-derived silyl enol ethers were employed. Their reaction with diaryliodonium salts as aryl source provided the intermolecular C–C coupling displaying good functional group tolerance and requiring low catalyst loading.

Alternative approach toward the generation of benzylic zinc reagent: Direct oxidative addition of active zinc into the carbon-oxygen bond of benzyl mesylates

The use of highly active zinc, prepared by the Rieke method, for the direct preparation of benzylic zinc mesylate was investigated. The oxidative addition of highly active zinc to benzyl mesylate was easily completed under mild conditions. The resulting benzylic zinc mesylates were employed in subsequent cross-coupling reactions with a broad range of electrophiles, and the formation of the corresponding products was successful.

Copper catalyzed arylation/C-C bond activation: An approach toward α-aryl ketones

An efficient arylation/C-C activation process was discovered. -Diketones with aryl halides (aryl iodides and aryl bromides) could undergo reaction smoothly in the presence of Cu(I) or Cu(II) salts in DMSO using K3 PO4 3H2 O without ligands. The role of H2 O was unprecedented, which assisted the C-C activation. Various -aryl ketones could be efficiently synthesized by this novel method. In situ monitoring of the formation of KOAc and experimentation relating to "a classic diagnostic technique for the participation of radical anion intermediates" revealed the preliminary mechanistic information for the reaction. This method is simple, general, and practical which complemented the classic method for the rapid construction of C-C bonds to a carbonyl moiety.