898825-89-3

Basic information

• Product Name: N-METHOXY-N-METHYL 5-THIAZOLECARBOXAMIDE
• Synonyms: N-Methoxy-N-methyl-1,3-thiazole-5-carboxamide98%;N-METHOXY-N-METHYL 5-THIAZOLECARBOXAMIDE;N-METHOXY-N-METHYL THIAZOLE-5-CARBOXAMIDE;N-Methoxy-N-methyl-1,3-thiazole-5-carboxamide;N-Methoxy-N-methyl-1,3-thiazole-5-carboxamide 98%
• CAS NO: 898825-89-3
• Molecular Formula: C₆H₈N₂O₂S
• Molecular Weight: 172.20492
• Product Categories: blocks;Thiazoles
• Mol File: 898825-89-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 54-56
• Boiling Point: 329.8 °C at 760 mmHg
• Flash Point: 153.3 °C
• Appearance: /
• Density: 1.287 g/cm³
• Vapor Pressure: 0.000173mmHg at 25°C
• Refractive Index: 1.553
• Storage Temp.: Keep Cold
• PKA: 0.70±0.10(Predicted)
• CAS DataBase Reference: N-METHOXY-N-METHYL 5-THIAZOLECARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-METHOXY-N-METHYL 5-THIAZOLECARBOXAMIDE(898825-89-3)
• EPA Substance Registry System: N-METHOXY-N-METHYL 5-THIAZOLECARBOXAMIDE(898825-89-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 898825-89-3(Hazardous Substances Data)

Usage

General Description

N-Methoxy-N-methyl 5-thiazolecarboxamide is a chemical compound that belongs to the group of thiazoles, which are aromatic heterocyclic compounds characterized by a ring structure containing both carbon and nitrogen atoms. The presence of the methoxy and methyl groups improves the overall stability of the compound, rendering it less reactive, which might be advantageous in chemical reactions. This chemical compound is typically synthesized in the lab and used for various research purposes and in the manufacture of pharmaceuticals or as an intermediate in organic synthesis. As with any chemical substances, N-Methoxy-N-methyl 5-thiazolecarboxamide should be handled, stored, and disposed of according to the appropriate safety guidelines.

InChI:InChI=1/C6H8N2O2S/c1-8(10-2)6(9)5-3-7-4-11-5/h3-4H,1-2H3

Upstream product

• 14527-41-4 thiazole-5-carboxylic acid 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 

Downstream Products

• 91516-28-8 1-(thiazol-5-yl) ethan-1-one 

Relevant articles and documents

Discovery of Hydroxyamidine Derivatives as Highly Potent, Selective Indoleamine-2,3-dioxygenase 1 Inhibitors

In this study, a series of novel hydroxyamidine derivatives were identified as potent and selective IDO1 inhibitors by structure-based drug design. Among them, compounds 13-15 and 18 exhibited favorable enzymatic and cellular activities. Compound 18 showed improved bioavailability in mouse, rat, and dog (F% = 44%, 58.8%, 102.1%, respectively). With reasonable in vivo pharmacokinetic properties, compound 18 was further evaluated in a transgenic MC38 xenograft mouse model. The combination of compound 18 with PD-1 monoclonal antibody showed a synergistic antitumor effect. These data indicated that compound 18 as a potential cancer immunotherapy agent should warrant further investigation.

HEPATITIS B CORE PROTEIN ALLOSTERIC MODULATORS

ABSTRACT The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

HETEROARYL LINKED QUINOLINYL MODULATORS OF RORGAMMAT

The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndr