89900-93-6Relevant articles and documents
Synthesis and biological evaluation of a novel photo-activated histone deacetylase inhibitor
Dear, Anthony E.,Liu, Hongbin,Mountford, Simon,Robinson, Andrea,Sama, Gopal R.,Thompson, Phillip
supporting information, (2020/06/05)
Hydroxamic acid-based histone deacetylase inhibitors (HDACi) are a class of epigenetic agents with potentially broad therapeutic application to several disease states including post angioplasty mediated neointimal hyperplasia (NIH). Precise spatiotemporal
Aryldiazonium Tetrafluoroborate Salts as Green and Efficient Coupling Partners for the Suzuki-Miyaura Reaction: From Optimisation to Mole Scale
Colleville, Aymeric P.,Horan, Richard A. J.,Tomkinson, Nicholas C. O.
, p. 1128 - 1136 (2015/04/22)
The use of aryldiazonium tetrafluoroborate salts as coupling partners in the Suzuki-Miyaura reaction was investigated from a process chemistry perspective including safety evaluation, solvent and catalyst screening and multivariate factor optimisation. Optimised conditions were applied to a range of substrates to evaluate the scope and limitations of the reaction, and one example was carried out on mole scale to demonstrate the practicality and scalability of the process.
Fast Suzuki-Miyaura cross-coupling reaction with hexacationic triarylphosphine Bn-dendriphos as ligand
Snelders, Dennis J. M.,Kreiter, Robert,Firet, Judith J.,Van Koten, Gerard,Gebbink, Robertus J. M. Klein
experimental part, p. 262 - 266 (2009/04/07)
The application of hexa[(dimethylamino)-methyl]-functionalized triphenylphosphine (1) and its benzylammonium salt, Bn-Dendriphos (2), in the Suzuki-Miyaura cross-coupling of aryl bromides with arylboronic acids is described. The 3,5-bis[(benzyldimethylammonio)methyl] substitution pattern in 2 leads to a rate enhancement compared to both the non-ionic parent compound 1 and triphenylphospine (PPh3) itself. At the same time, the resulting catalytic species are stable towards palladium black formation, even at a phosphine/palladium ratio of 1. These observations are attributed to the presence of a total of six ammonium groups in the backbone of the phosphine ligand, which presumably leads to an unsaturated phosphine-palladium complex.