89928-06-3Relevant articles and documents
TOTAL SYNTHESIS AND PROPERTIES OF PROSTAGLANDINS 35. SYNTHESIS AND PROPERTIES OF 4-CARBOMETHOXYALKYLAMINOMETHYLENE-(+)2-OXABICYCLO-6-OCTEN-3-ONES
Dikovskaya, K. I.,Mazur, T. V.,Turovskii, I. V.,Gavars, M. P.,Freimanis, Ya. F.
, p. 635 - 641 (1993)
Reaction of (+)4-mesyloxymethylene-2-oxabicyclo-6-octen-3-one with ω-amino acids of different lengths gave (+)4-carbomethoxyalkylaminomethylene-2-oxabicyclo-6-octen-3-ones.For the γ-aminobutyric ester, the corresponding aminomethylene deriva
SUBSTITUTED HYDANTOINAMIDES AS ADAMTS7 ANTAGONISTS
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Page/Page column 189-190, (2021/05/21)
The application relates to substituted hydantoinamides of formula (I) as ADAMTS7 antagonists, to processes for their preparation, their use alone or in combination for the treatment or prophylaxis of diseases, in particular of cardiovascular diseases, including atherosclerosis, coronary artery disease (CAD), peripheral vascular disease (PAD), arterial occlusive disease or restenosis after angioplasty. R1 is hydrogen, alkyl, cycloalkyl, heterocycloalkyl, 5- to 6-membered heteroaryl or phenyl; R2 is hydrogen or alkyl; A is 5-membered heteroaryl; Z is 6- to 10-membered aryl or 5- to 10-membered heteroaryl; all groups being optionally substituted.
Microwave-Assisted Ruthenium-Catalysed ortho-C?H Functionalization of N-Benzoyl α-Amino Ester Derivatives
Sharma, Nandini,Bahadur, Vijay,Sharma, Upendra K.,Saha, Debasmita,Li, Zhenghua,Kumar, Yogesh,Colaers, Jona,Singh, Brajendra K,Van der Eycken, Erik V.
supporting information, p. 3083 - 3089 (2018/08/24)
A microwave-assisted highly efficient intermolecular C?H functionalization sequence has been developed to access substituted isoquinolones using α-amino acid esters as a directing group. This methodology enables a wide range of N-benzoyl α-amino ester derivatives to react via a Ru-catalysed C?H bond activation sequence, to form isoquinolones with moderate to excellent yields. As an additional advantage, our strategy proved to be widely applicable and also enabled the reaction of alkenes to provide access to alkenylated benzamides. The methodology was also extended towards the synthesis of isoquinoline alkaloids derivatives viz. oxyavicine and a dipeptide. The developed protocol is simple and cheap, avoids tedious workup procedures and works efficiently under MW irradiation. (Figure presented.).
