89937-52-0

Basic information

• Product Name: 4-(2-AMINOETHYL)THIOMORPHOLINE 1,1-DIOXIDE
• Synonyms: 1-DIOXIDE-4-THIOMORPHOLINEPROPANEETHANAMINE;2-(1,1-DIOXOTHIOMORPHOLINO)ETHYLAMINE;4-THIOMORPHOLINEETHYLAMINE 1,1-DIOXIDE;4-(2-AMINOETHYL)THIOMORPHOLINE 1,1-DIOXIDE;N-(2-AMINOETHYL) THIOMORPHOLINE 1,1-DIOXIDE;1-DIXOIDE-4-AMINOETHYL THIOMORPHOLINE;2-(1,1-Dioxido-4-thiomorpholinyl)ethanamine
• CAS NO: 89937-52-0
• Molecular Formula: C₆H₁₄N₂O₂S
• Molecular Weight: 178.25
• Mol File: 89937-52-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 92 °C
• Boiling Point: 182 °C / 1mmHg
• Flash Point: 178.8 °C
• Appearance: /
• Density: 1.226 g/cm³
• Vapor Pressure: 9.92E-06mmHg at 25°C
• Refractive Index: 1.518
• Storage Temp.: 2-8°C
• PKA: 9.75±0.10(Predicted)
• CAS DataBase Reference: 4-(2-AMINOETHYL)THIOMORPHOLINE 1,1-DIOXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-AMINOETHYL)THIOMORPHOLINE 1,1-DIOXIDE(89937-52-0)
• EPA Substance Registry System: 4-(2-AMINOETHYL)THIOMORPHOLINE 1,1-DIOXIDE(89937-52-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 89937-52-0(Hazardous Substances Data)

Usage

Uses

4-(2-Aminoethyl)thiomorpholine 1,1-dioxide is used as a reactant in the synthesis of betulinic acid derivatives as inhibitors of HIV maturation.

InChI:InChI=1/C6H14N2O2S/c7-1-2-8-3-5-11(9,10)6-4-8/h1-7H2

Upstream product

• 79207-43-5 4-Cyanomethyl-thiomorpholin-S-dioxid 

Downstream Products

• 173337-84-3 5(S)-tert-butoxycarbonylamino-4(S)-hydroxy-7(S)-isopropyl-2(R)-methyl-8-[4-methoxy-3-(3-methoxypropyloxy)-phenyl]-octanoic acid N-[2-(1,1-dioxothiomorpholino)ethyl] amide 
• 1021869-47-5 C₂₃H₃₂N₄O₆S₂ 
• 1117686-28-8 4-{[4-(2,6-dimethylpyridin-3-yl)oxypyridin-2-yl]amino}-N-[2-(1,1-dioxo-1,4-thiazinan-4-yl)ethyl]benzamide 
• 1229021-64-0 C₂₃H₂₃N₅O₃S 
• 1300746-38-6 2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-[2-(1,1-dioxido-4-thiomorpholinyl)ethyl]acetamide 
• 1351278-73-3 (4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-((2-(1,1-dioxidothiomorpholino)ethyl)carbamoyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)phenyl)boronic acid trifluoroacetate 
• 1226916-86-4 N-[2-(1,1-Dioxidothiomorpholin-4-yl)ethyl]-5-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]pyridine-2-amine 
• 1256969-00-2 2-((N-(2-thiamorpholin-1,1-dioxide-4-yl)ethyl)-2-nitroanilin-4-yl)benzoxazole 
• 1392314-23-6 N-(2-((tert-butyl(dimethyl)silyl)oxy)propyl)-N-(2-(1,1-dioxido-4-thiomorpholinyl)ethyl)-2-nitrobenzenesulfonamide 
• 1392314-24-7 N-(3-((tert-butyl(dimethyl)silyl)oxy)propyl)-N-(2-(1,1-dioxido-4-thiomorpholinyl)ethyl)-2-nitrobenzenesulfonamide 
• 1392314-26-9 N-(2-(1,1-dioxido-4-thiomorpholinyl)ethyl)-N-(2-methoxyethyl)-2-nitrobenzenesulfonamide 
• 1392314-27-0 N-(2-(1,1-dioxido-4-thiomorpholinyl)ethyl)-N-(3-methoxypropyl)-2-nitrobenzenesulfonamide 
• 1392314-28-1 N,N-bis(2-(1,1-dioxido-4-thiomorpholinyl)ethyl)-2-nitrobenzenesulfonamide 
• 1392314-22-5 N-(2-(1,1-dioxido-4-thiomorpholinyl)ethyl)-2-nitrobenzenesulfonamide 

Relevant articles and documents

Aryl compounds with aminoalkyl substituents and their use

The present application relates to novel aryl compounds with aminoalkyl substituents, to processes for their preparation, to their use for treatment and/or prevention of diseases and to their use for the preparation of medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of hyperproliferative and angiogenic diseases and those diseases which arise from metabolic adaptation to hypoxic states. Such treatments can be carried out as monotherapy or also in combination with other medicaments or further therapeutic measures.