89946-68-9

Basic information

• Product Name: 1H-IMidazole-4,5-dicarboxylic acid, 2-ethyl-, diethyl ester
• Synonyms: 1H-IMidazole-4,5-dicarboxylic acid, 2-ethyl-, diethyl ester
• CAS NO: 89946-68-9
• Molecular Formula: C₁₁H₁₆N₂O₄
• Molecular Weight: 240.25574
• Mol File: 89946-68-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-IMidazole-4,5-dicarboxylic acid, 2-ethyl-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-IMidazole-4,5-dicarboxylic acid, 2-ethyl-, diethyl ester(89946-68-9)
• EPA Substance Registry System: 1H-IMidazole-4,5-dicarboxylic acid, 2-ethyl-, diethyl ester(89946-68-9)

Safety Data

• Hazardous Substances Data: 89946-68-9(Hazardous Substances Data)

Usage

Molecular Structure

1H-Imidazole-4,5-dicarboxylic acid, 2-ethyl-, diethyl ester is a derivative of 1H-Imidazole-4,5-dicarboxylic acid with two ethyl groups attached to the carboxylic acid groups as ester functional groups.

Physical Properties

It is a white to off-white crystalline solid.

Uses

It is commonly used in the pharmaceutical and chemical industries, and has potential applications in the development of drugs and medicines, as well as in the synthesis of other organic compounds.

Safety

It is important to handle this chemical with care and follow proper safety protocols when working with it in a laboratory or industrial setting.

Upstream product

• 58954-22-6 2-ethyl-1H-imidazole-4,5-dicarboxylic acid 
• 64-17-5 ethanol 
• 57610-38-5 2-ethyl-1H-imidazole-4,5-dicarbonitrile 

Downstream Products

• 144689-66-7 ethyl 1-[(2'-carboxybiphenyl-4-yl)methyl]-2-ethyl-4-(1-hydroxy-1-methylethyl)imidazole-5-carboxylate 
• 144689-65-6 ethyl 1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-2-ethyl-4-(1-hydroxy-1-methylethyl)imidazole-5-carboxylate 
• 144689-68-9 ethyl 2-ethyl-4-(1-hydroxy-1-methylethyl)-1-{4-[2-(tetrazol-5-yl)-phenyl]phenyl}methylimidazole-5-carboxylate 
• 172875-58-0 2-Ethyl-5-(1-hydroxy-1-methyl-ethyl)-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid ethyl ester 
• 153283-63-7 diethyl 1-benzyl-2-ethylimidazole-4,5-dicarboxylate 

Relevant articles and documents

ANGIOTENSIN II ANTAGONIST 1-BIPHENYLMETHYLIMIDAZOLE COMPOUNDS AND THEIR THERAPEUTIC USE

Compounds of the following formula (I) or the formula (I) p : STR1 wherein R 1 is alkyl or alkenyl; R 2 and R 3 are hydrogen, alkyl, alkenyl, cycloalkyl, aralkyl, aryl, or aryl fused to cycloalkyl; R 4 is hydrogen, alkyl, alkanoyl, alkenoyl, arylcarbonyl, alkoxycarbonyl, tetrahydropyranyl, tetrahydrothiopyranyl, tetrahydrothienyl, tetrahydrofuryl, a group of formula--SiR a R b R c, in which R a, R b and R c are alkyl or aryl, alkoxymethyl, (alkoxyalkoxy)methyl, haloalkoxymethyl, aralkyl, aryl or alkanoyloxymethoxycarbonyl; R 5 is carboxy or--CONR 8 R 9, wherein R 8 and R 9 hydrogens or alkyl, or R 8 and R 9 together form alkylene; R 6 is hydrogen, alkyl, alkoxy or halogen; R. sup.7 is carboxy or tetrazol-5-yl; R p. sup.1 is hydrogen, alkyl, cycloalkyl or alkanoyl; R p 2 is a single bond, alkylene or alkylidene; R p 3 and R p 4 are each hydrogen or alkyl; R. sub.p 6 is carboxy or tetrazol-5-yl; and X p is oxygen or sulfur; and pharmaceutically acceptable salts and esters thereof. The compounds are AII receptor antagonists and thus have hypotensive activity and can be used for the treatment and prophylaxis of hypertension. The compounds may be prepared by reacting a biphenylmethyl compound with an imidazole compound.