89976-15-8Relevant articles and documents
Preparation of 7-halo-indoles by thallation of N-formylindoline and their attempted use for synthesis of the right-hand segment of chloropeptin
Yamada, Yaeko,Arima, Shiho,Okada, Chiharu,Akiba, Ai,Kai, Toshitsugu,Harigaya, Yoshihiro
, p. 788 - 794 (2007/10/03)
7-Substituted (Cl, Br, I) indoles were synthesized by using thallation of N-formylindoline as a key reaction. Two precursor tripeptides for the right-hand segment of chloropeptin were synthesized by using (R)-7′-iodo and 7′-bromotryptophans derived from each 7-substituted indole (I, Br) obtained by the above procedure.
The Chemistry of Indoles. XXXIX. A Facile Synthetic Method for 7-Substituted Indoles
Somei, Masanori,Saida, Yoshihiro,Funamoto, Tetsuo,Ohta, Toshihara
, p. 3146 - 3154 (2007/10/02)
A simple four-step synthetic method for 7-iodo-, 7-bromo- and 7-chloroindole was established with high overall yield starting from 2,3-dihydroindole.Several 7-substituted indoles carrying a carbon side chain and 7-methoxyindole were also synthetized.Keywords - thallation; 7-substituted indole; regioselective metalation; 7-iodoindole; 7-bromoindole; 7-chloroindole; 7-methoxyindole; methyl 3-(indol-7-yl)acrylate; 4-(indol-7-yl)-2-methyl-3-buten-2-ol; Heck reaction