899821-15-9

Basic information

• Product Name: 2-chloro-4-(3-endo-hydroxy-8-azabicyclo[3.2.1]oct-8-yl)benzonitrile
• Synonyms: 2-chloro-4-(3-endo-hydroxy-8-azabicyclo[3.2.1]oct-8-yl)benzonitrile
• CAS NO: 899821-15-9
• Molecular Weight: 262.739
• Mol File: 899821-15-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-chloro-4-(3-endo-hydroxy-8-azabicyclo[3.2.1]oct-8-yl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-4-(3-endo-hydroxy-8-azabicyclo[3.2.1]oct-8-yl)benzonitrile(899821-15-9)
• EPA Substance Registry System: 2-chloro-4-(3-endo-hydroxy-8-azabicyclo[3.2.1]oct-8-yl)benzonitrile(899821-15-9)

Safety Data

• Hazardous Substances Data: 899821-15-9(Hazardous Substances Data)

Upstream product

• 60702-69-4 2-chloro-4-fluorobenzonitrile 
• 143557-91-9 (1R,3S,5S)-tert-butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 538-09-0 nortropine 

Relevant articles and documents

Synthesis and biological evaluation of second-generation tropanol-based androgen receptor modulators

To circumvent antiandrogen resistance in prostate cancer, antiandrogens effective for both the androgen receptor (AR) and AR mutants are required. The AR antagonists in this study originate from previous findings, which showed that subtle differences in substitution pattern lead to a conformational change that alters the ligand activity, rendering an agonist to an antagonist. We have identified small yet potent tropanol-based ligands possessing significant antiandrogenic activity with both wild-type AR and the two most common AR ligand binding domain (LBD) mutants.