89985-53-5

Basic information

• Product Name: 2-(1-aminoethyl)phenol
• Synonyms: 2-(1-aminoethyl)phenol;2-(1-aminoethyl)phenol(SALTDATA: HCl)
• CAS NO: 89985-53-5
• Molecular Formula: C₈H₁₁NO
• Molecular Weight: 137.18
• Mol File: 89985-53-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 246.3°C at 760 mmHg
• Flash Point: 102.8°C
• Appearance: /
• Density: 1.096g/cm³
• Vapor Pressure: 0.0174mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-(1-aminoethyl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-aminoethyl)phenol(89985-53-5)
• EPA Substance Registry System: 2-(1-aminoethyl)phenol(89985-53-5)

Safety Data

• Hazardous Substances Data: 89985-53-5(Hazardous Substances Data)

Usage

General Description

2-(1-aminoethyl)phenol, also known as 2-Amino-1-phenylethanol, is an organic compound with the chemical formula C8H11NO. It is a colorless to pale yellow liquid with a slight odor. This chemical is often used in the production of pharmaceuticals, dyes, and as an intermediate in organic synthesis. It is also utilized as a chelating and complexing agent in analytical chemistry. 2-(1-aminoethyl)phenol has various applications in the medical and cosmetic industries, and is used as an ingredient in hair dyes and skincare products. Additionally, it has potential biological and pharmacological properties, making it an interesting compound for further research in pharmaceutical development.

InChI:InChI=1/C8H11NO/c1-6(9)7-4-2-3-5-8(7)10/h2-6,10H,9H2,1H3

Upstream product

• 1196-29-8 2-hydroxyacetophenoneoxime 
• 909394-43-0 2-{1-[(6-chloro-pyridin-2-yl)-hydrazono]-ethyl}-phenol 
• 21895-22-7 2-(1-iminoethyl)phenol 
• 118-93-4 o-hydroxyacetophenone 
• 21895-22-7 2’-hydroxyacetophenone imine 
• 1422447-35-5 2-(1-p-tosylethyl)phenol 
• 3376-33-8 O-methyl acetophenone oxime 
• 54758-74-6 1-(2-hydroxyphenyl)ethan-1-one O-methyl oxime 

Downstream Products

• 89985-54-6 2-(1-salicylidenamino-ethyl)-phenol 
• 123982-82-1 (+)-1-(2-benzyloxyphenyl)ethylamine 
• 1105678-26-9 3-{[1-(2-hydroxyphenyl)ethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione 
• 123983-05-1 2?[(1R)?1-aminoethyl]phenol 
• 133511-37-2 2-[(1S)-1-aminoethyl]phenol 
• 932-30-9 2-Hydroxybenzylamine 

Relevant articles and documents

Ruthenium-Catalyzed Direct Asymmetric Reductive Amination of Diaryl and Sterically Hindered Ketones with Ammonium Salts and H2

A Ru-catalyzed direct asymmetric reductive amination of ortho-OH-substituted diaryl and sterically hindered ketones with ammonium salts is reported. This method represents a straightforward route toward the synthesis of synthetically useful chiral primary diarylmethylamines and sterically hindered benzylamines (up to 97 % yield, 93–>99 % ee). Elaborations of the chiral amine products into bioactive compounds and a chiral ligand were demonstrated through manipulation of the removable and convertible -OH group.

Ligand-Promoted Pd-Catalyzed Oxime Ether Directed C-H Hydroxylation of Arenes

An efficient Pd-catalyzed oxime ether directed ortho C-H hydroxylation of arenes under neutral conditions has been developed. The efficiency of this hydroxylation is significantly improved by a ligand. Oxone, an inexpensive, readily available, and safe reagent, was employed as terminal oxidant and oxygen source. The challenging electron-deficient substrates could also be monohydroxylated in high efficiency. Drug modification with this protocol was also successfully demonstrated.

Direct enantioseparation of 1-(2-hydroxyphenyl) ethylamines via diastereomeric salt formation: Chiral recognition mechanism based on the crystal structure

In this study, the direct enantioseparation of unprotected 1-(2-hydroxyphenyl)ethylamines (1a and 1b) via diastereomeric salt formation is reported. After the one-pot synthesis of racemic 1, the screening of seven acidic chiral resolving agents showed tha