90-91-5

Basic information

• Product Name: 2,2-Dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-[4-(methylsulfonyl)pheny l]ethyl)acetamide
• Synonyms: 2,2-Dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-[4-(methylsulfonyl)pheny l]ethyl)acetamide;Aza-atp
• CAS NO: 90-91-5
• Molecular Weight: 0
• Mol File: 90-91-5.mol
• Article Data: 22

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,2-Dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-[4-(methylsulfonyl)pheny l]ethyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-Dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-[4-(methylsulfonyl)pheny l]ethyl)acetamide(90-91-5)
• EPA Substance Registry System: 2,2-Dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-[4-(methylsulfonyl)pheny l]ethyl)acetamide(90-91-5)

Safety Data

• Hazardous Substances Data: 90-91-5(Hazardous Substances Data)

Upstream product

• 14052-59-6 D-threo-1-p-methylmercaptophenyl-2-dichloroacetamidopropane-1,3-diol 
• 119293-92-4 (+/-)-2-dichloroacetamido-β-hydroxy-4-methylmercaptopropiophenone 
• 116-54-1 dichloroacetic acid methyl ester 
• 51458-28-7 (1R,2R)-2-amino-1-<4-(methylsulphonyl)phenyl>-1,3-propanediol 
• 1768-31-6 pentachloroacetone 
• 872302-03-9 dichloroacetyl-phosphorous acid diethyl ester 
• 4302-89-0 (1R,2R)-2-(2,2-dichloro-acetylamino)-1-(4-methylsulfanyl-phenyl)-propane-1,3-diol 
• 903506-29-6 4-[(1R,2R)-2-(2,2-dichloro-acetylamino)-1,3-dihydroxy-propyl]-benzenesulfinic acid 
• 74-88-4 methyl iodide 
• 108656-27-5 (1R,2S)-2-(2,3-dimethylbenzoyl)amino-3-fluoro-1-<4-(methylsulphonyl)phenyl>-1-propanol 
• 3018-12-0 dichloroacetonitrile 
• 912296-98-1 2,2-dichloro-N-[1-hydroxymethyl-2-methoxy-2-(4-methanesulfonyl-phenyl)-ethyl]-acetamide 
• 96795-22-1 (4R,5R)-4-hydroxymethyl-5-<4-(methylsulphonyl)phenyl>-2-oxazolidinone 
• 912296-97-0 syn-(2R,3R)-[2-amino-3-methoxy-3-(4-methanesulfonyl-phenyl)-1-propanol] 

Downstream Products

• 21478-01-3 threo-(1R,2R)-1-<(4-methylsulfonyl)phenyl>-2-(dichloroacetamido)-1,3-propanediol 3-palmitate 

Relevant articles and documents

Method for continuously preparing thiamphenicol by using micro-reaction system

The invention belongs to the technical field of pharmaceutical engineering, and particularly relates to a method for continuously preparing thiamphenicol by using a micro-reaction system. A micro-reaction system used in the method comprises a micro-mixer, a micro-channel reactor and a back pressure device, and during preparation, a solution of raw materials (1R,2R)-2-amino-1-(4-(methylsulfonyl)phenyl)propane-1,3-diol and an alkaline solution of methyl dichloroacetate are simultaneously injected into the micro-reactor by a pump respectively for condensation reaction, and concentrating, recrystallizing, filtering, washing and drying are conducted on the reaction product to obtain a thiamphenicol product. According to the method provided by the invention, the reaction time is only several minutes, the yield of the product thiamphenicol is greater than 99%, the purity is greater than 99%, the operation is convenient, continuous and controllable, the amplification effect is avoided, the efficiency of the technological process is high, and the method has a very good industrial application prospect.

Unified Strategy to Amphenicol Antibiotics: Asymmetric Synthesis of (-)-Chloramphenicol, (-)-Azidamphenicol, and (+)-Thiamphenicol and Its (+)-3-Floride

The asymmetric synthesis of (-)-chloramphenicol, (-)-azidamphenicol, and (+)-thiamphenicol and its (+)-3-floride, (+)-florfenicol, is reported. This approach toward the amphenicol antibiotic family features two key steps: (1) a cinchona alkaloid derived urea-catalyzed aldol reaction allows highly enantioselective access to oxazolidinone gem-diesters and (2) a continuous flow diastereoselective decarboxylation of thermally stable oxazolidinone gem-diesters to form the desired trans-oxazolidinone monoesters with two adjacent stereocenters that provide the desired privileged scaffolds of syn-vicinal amino alcohols in the amphenicol family.

Florfenicol intermediate synthesis method

The invention belongs to the field of synthesis of pharmaceutical raw materials, and specifically discloses a florfenicol intermediate synthesis method, which comprises: (1) carrying out a reaction ona compound (II) and an acylating reagent in an organic solvent to form a compound (III); (2) carrying out a reaction on the compound (III) and an oxidizing agent in an organic solvent in the presenceof a catalyst to form a compound (IV); (3) carrying out a reaction on the compound (IV) and a fluorinating reagent in an organic solvent to form a compound (V); and (4) carrying out acidolysis on thecompound (V) in an organic solvent, and carrying out deprotection to obtain a compound (I), wherein various groups in the formulas are defined in the specification. According to the present invention, the florfenicol intermediate can be used for preparing florfenicol; and the method has characteristics of novel design, mild conditions and simple operation, and is suitable for industrial production.