9000-40-2

Basic information

• Product Name: LOCUST BEAN GUM
• Synonyms: Carobbeanextract;carobflour;Carobgum;carobseedgum;ceratoniagum;fructoline;indalcaabv;johannisbrotmehl
• CAS NO: 9000-40-2
• Molecular Formula: C10H11ClN2O2
• Molecular Weight: 226.65954
• EINECS: 232-541-5
• Mol File: 9000-40-2.mol
• Article Data: 0

Chemical Properties

• Appearance: Off-white to yellow-green powder
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Ceratonia is dispersible in hot water, forming a sol having a pH 5.4–7.0 that may be converted to a gel by the addition of small amounts of sodium borate. In cold water, ceratonia hydrates very slowly and incompletely. Ceratonia is practically insoluble in ethanol.
• CAS DataBase Reference: LOCUST BEAN GUM(CAS DataBase Reference)
• NIST Chemistry Reference: LOCUST BEAN GUM(9000-40-2)
• EPA Substance Registry System: LOCUST BEAN GUM(9000-40-2)

Safety Data

• WGK Germany: 2
• RTECS: OJ8690000
• F: 3
• Hazardous Substances Data: 9000-40-2(Hazardous Substances Data)

Usage

Uses

Used in Food Industry:
Locust Bean Gum is used as a food stabilizer and thickener, providing high viscosity and improving the texture of processed cheese, ice cream, bakery products, soups, and pies. It also functions as a water binder and can make agar or carrageenan gels more elastic. The typical usage level is 0.1–1.0%.
Used in Pharmaceutical Industry:
LBG may be used in the development of drug delivery devices, serving as a carrier or encapsulating agent for various pharmaceutical applications.
Used in Enzyme Research:
Locust Bean Gum may be used as a substrate to help identify, differentiate, and characterize mannanases, such as the β-Mannanases (EC 3.2.1.78), which are enzymes that break down mannans.
Used in Material Science:
LBG may be used to study its properties as a protective agent on both eucalyptus and microcrystalline cellulose, preventing the destruction of crystallinity by ball milling.
Used in Food Preservation:
LBG may be used as a food additive to reduce spoilage caused by Aspergillus flavus, a fungus that can contaminate food products.
Used in Organic Synthesis:
Locust Bean Gum may be used as a starting material for the organic synthesis of hyperbranched N-glycan core structures, which have potential applications in various fields.

Production Methods

Ceratonia is a naturally occurring material obtained from the ground endosperms separated from the seeds of the locust bean tree, Ceratonia siliqua (Leguminosae). The tree is indigenous to southern Europe and the Mediterranean region.

Air & Water Reactions

Insoluble in water.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition LOCUST BEAN GUM emits acrid smoke and fumes.

Fire Hazard

Flash point data for LOCUST BEAN GUM are not available. However, LOCUST BEAN GUM is probably combustible.

Pharmaceutical Applications

Ceratonia is a naturally occurring material generally used as a substitute for tragacanth or other similar gums. A ceratonia mucilage that is slightly more viscous than tragacanth mucilage may be prepared by boiling 1.0–1.5% of powdered ceratonia with water. As a viscosity-increasing agent, ceratonia is said to be five times as effective as starch and twice as effective as tragacanth. Ceratonia has also been used as a tablet binder and is used in oral controlled-release drug delivery systems approved in Europe and the USA. Ceratonia is widely used as a binder, thickening agent, and stabilizing agent in the cosmetics and food industry. In foods, 0.15–0.75% is used. Therapeutically, ceratonia mucilage is used orally in adults and children to regulate intestinal function.

Safety Profile

Mildly toxic by ingestion. When heated to decomposition it emits acrid smoke and irritating fumes.

Safety

Ceratonia is generally regarded as an essentially noncarcinogenic, nontoxic and nonirritant material. Therapeutically, it has been used in oral formulations for the control of vomiting and diarrhea in adults and children; 20–40 g daily in adults has been used dispersed in liquid. As an excipient, ceratonia is used in oral controlledrelease formulations approved in Europe and the USA. Ceratonia is also widely used in food products. The WHO has not specified an acceptable total daily intake for ceratonia as the total daily intake arising from its use at the levels necessary to achieve the desired effect, and from its acceptable background in food, was not considered to represent a hazard to health. Ceratonia hypersensitivity has been reported, in a single case report, in an infant. However, ceratonia is said to be nonallergenic in children with known allergy to peanuts. LD50 (hamster, oral): 10.0 g/kg LD50 (mouse, oral): 13.0 g/kg LD50 (rabbit, oral): 9.1 g/kg LD50 (rat, oral): 13.0 g/kg

storage

The bulk material should be stored in a well-closed container in a cool, dry place. Ceratonia loses not more than 15% of its weight on drying.

Incompatibilities

The viscosity of xanthan gum solutions is increased in the presence of ceratonia. This interaction is used synergistically in controlledrelease drug delivery systems.

Regulatory Status

GRAS listed. Accepted for use in Europe as a food additive. In Europe and the USA, ceratonia has been used in oral tablet formulations.