9001-81-4

Basic information

• Product Name: EC 5.4.2.2
• Synonyms: PGLUM;PHOSPHOGLUCOMUTASE;PHOSPHOGLUCOMUTASE RABBIT MUSCLE;ALPHA-D-GLUCOSE-1,6-BISPHOSPHATASE;ALPHA-D-GLUCOSE-1,6-PHOSPHOMUTASE;ALPHA-D-GLUCOSE 1-PHOSPHATE PHOSPHOTRANSFERASE;EC 5.4.2.2;phosphoglucomutase from rabbit muscle
• CAS NO: 9001-81-4
• Molecular Formula: NULL
• Molecular Weight: 0
• EINECS: 232-634-0
• Product Categories: enzyme
• Mol File: 9001-81-4.mol
• Article Data: 0

Chemical Properties

• Appearance: /ammonium sulfate suspension
• Density: 1.00 g/mL at 20 °C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: EC 5.4.2.2(CAS DataBase Reference)
• NIST Chemistry Reference: EC 5.4.2.2(9001-81-4)
• EPA Substance Registry System: EC 5.4.2.2(9001-81-4)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 1
• Hazardous Substances Data: 9001-81-4(Hazardous Substances Data)

Usage

Description

EC 5.4.2.2, also known as phosphoglucomutase (PGM), is an enzyme that catalyzes the reversible transfer of a phosphoryl group between glucose-1-phosphate and glucose-6-phosphate. It is a single polypeptide chain made up of four α/β domains, forming a compact heart-shaped structure with a large fissure between the two lobes. The active enzymatic site of the molecule is located at the bottom of the crevice on the surface of domain I. Rabbit muscle phosphoglucomutase (RB-PGM) is a monomer with a unique four-domain architecture. It is a white to light yellow solid.

Uses

Used in Research Applications:
EC 5.4.2.2 is used as a research tool for investigating the hexose bisphosphate activation of phosphoglucomutase. It helps in understanding the role of this enzyme in various metabolic pathways.
Used in Biochemical Reactions:
EC 5.4.2.2 is used as a catalyst in biochemical reactions to facilitate the exchange of a phosphoryl group between glucose-1-phosphate and glucose-6-phosphate. This reaction is crucial for the interconversion of these two important metabolic intermediates.
Used in Pharmaceutical Industry:
EC 5.4.2.2 can be used in the development of drugs targeting metabolic disorders. Its ability to catalyze the reversible transfer of a phosphoryl group makes it a potential target for therapeutic intervention in conditions related to glucose metabolism.
Used in Diagnostic Applications:
EC 5.4.2.2 can be used as a diagnostic marker to assess the activity of this enzyme in various diseases and conditions. Abnormal levels of phosphoglucomutase may indicate metabolic disorders or other health issues.
Used in Enzyme Replacement Therapy:
In cases where there is a deficiency of EC 5.4.2.2, enzyme replacement therapy can be employed to provide the necessary enzyme to restore normal metabolic function. This can be particularly useful in treating genetic disorders affecting the production or function of phosphoglucomutase.

Biochem/physiol Actions

Phosphoglucomutase (PGM) mainly catalyzes the interconversion of glucose 1-phosphate and glucose 6-phosphate via a glucose 1,6-diphosphate intermediate. Hence it plays a key role in glycolysis and gluconeogenesis.