9001-87-0 Usage
Description
EC 3.1.4.4 TYPE IV, also known as Phospholipase D (PLD), is a ubiquitous enzyme with a molecular weight of approximately 50,000 Da. It is expressed in a variety of plant tissues, a few microorganisms, and some mammalian tissues. PLD catalyzes the hydrolysis of the phosphate bonds of phospholipids and sphingomyelin to produce the corresponding phosphatidic acid. It plays a crucial role in various cellular processes, including signal transduction, membrane trafficking, and vesicle formation.
Uses
Used in Biochemical Research:
EC 3.1.4.4 TYPE IV is used as a research tool for studying metabolic labeling and direct imaging of choline phospholipids in vivo by measuring propargyl-Cho incorporation. This helps researchers understand the dynamics and regulation of phospholipid metabolism.
Used in Purification and Kinetic Studies:
PLD is employed in purification and kinetic studies to investigate the enzyme's properties, substrate specificity, and catalytic mechanisms. This information is essential for developing potential therapeutic agents targeting PLD or its associated pathways.
Used in Pharmaceutical Industry:
EC 3.1.4.4 TYPE IV has potential applications in the pharmaceutical industry as a target for drug development. Inhibitors or activators of PLD could be used to modulate cellular processes and treat various diseases, such as cancer, neurodegenerative disorders, and cardiovascular diseases, where PLD activity is implicated.
Used in Food Industry:
Phospholipase D from Streptomyces chromofuscus has been used to cleave choline-containing phospholipids (PCs) in the food industry. This application can improve the texture, flavor, and shelf life of food products by modifying the lipid composition.
Biochem/physiol Actions
Phospholipase D is glycerophospholipid-specific. It is markedly less active on sphingomyelins and lysophospholipids. Phospholipase D hydrolyzes the phosphate bonds of phospholipids and sphingomyelin to give the corresponding phosphatidic acid.
Check Digit Verification of cas no
The CAS Registry Mumber 9001-87-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,0 and 1 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 9001-87:
(6*9)+(5*0)+(4*0)+(3*1)+(2*8)+(1*7)=80
80 % 10 = 0
So 9001-87-0 is a valid CAS Registry Number.
