900186-72-3 Usage
Description
(3R,3aS,4S,4aS,7R,9aR)-3-Methyl-7-nitro-1-oxo-N,N-diphenyl-1,3,3a,4,4a,5,6,7,8,9a-decahydronaphtho[2,3-c]furan-4-carboxamide is a complex organic compound with a unique molecular structure. It is a derivative of Himbacine (H456343), an alkaloid muscarinic receptor antagonist, and possesses a decahydronaphtho[2,3-c]furan-4-carboxamide core with various substituents, including a methyl, nitro, and oxo group.
Uses
Used in Pharmaceutical Industry:
(3R,3aS,4S,4aS,7R,9aR)-3-Methyl-7-nitro-1-oxo-N,N-diphenyl-1,3,3a,4,4a,5,6,7,8,9a-decahydronaphtho[2,3-c]furan-4-carboxamide is used as a muscarinic receptor antagonist for the development of drugs targeting various conditions. Its antagonistic properties allow it to modulate the activity of muscarinic receptors, which play a crucial role in various physiological processes. (3R,3aS,4S,4aS,7R,9aR)-3-Methyl-7-nitro-1-oxo-N,N-diphenyl-1,3,3a,4,4a,5,6,7,8,9a-decahydronaphtho[2,3-c]furan-4-carboxamide may have potential applications in the treatment of disorders related to the muscarinic receptor system, such as Alzheimer's disease, urinary incontinence, and overactive bladder.
Used in Research Applications:
In addition to its potential pharmaceutical applications, (3R,3aS,4S,4aS,7R,9aR)-3-Methyl-7-nitro-1-oxo-N,N-diphenyl-1,3,3a,4,4a,5,6,7,8,9a-decahydronaphtho[2,3-c]furan-4-carboxamide can be used as a research tool to study the structure-activity relationships of muscarinic receptor antagonists. Its unique molecular structure allows researchers to investigate the effects of different functional groups on the compound's binding affinity and selectivity for muscarinic receptors, contributing to the development of more effective and targeted drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 900186-72-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,0,0,1,8 and 6 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 900186-72:
(8*9)+(7*0)+(6*0)+(5*1)+(4*8)+(3*6)+(2*7)+(1*2)=143
143 % 10 = 3
So 900186-72-3 is a valid CAS Registry Number.
900186-72-3Relevant articles and documents
Thrombin Receptor Antagonists Based On The Modified Tricyclic Unit Of Himbacine
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Page/Page column 30-31, (2008/06/13)
Multiple stereoisomers of the heterocyclic-substituted tricyclics of the formula: or a pharmaceutically acceptable salt, solvate, or ester of said compound wherein R and the stereochemistry are illustrated in the structural formulas herein are disclosed, as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, and cancer by administering said compounds. Combination therapy with other cardiovascular agents is also claimed.