900510-03-4

Basic information

• Product Name: PF-3274167
• Synonyms: PF-3274167;PF-03274167;5-[3-[3-(2-Chloro-4-fluorophenoxy)-1-azetidinyl]-5-(methoxymethyl)-4H-1,2,4-triazol-4-yl]-2-methoxypyridine;5-[3-[3-(2-chloro-4-fluorophenoxy)azetidin-1-yl]-5-(methoxymethyl)-1,2,4-triazol-4-yl]-2-methoxypyridine;Cligosiban
• CAS NO: 900510-03-4
• Molecular Formula: C19H19ClFN5O3
• Molecular Weight: 419.84
• Mol File: 900510-03-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: PF-3274167(CAS DataBase Reference)
• NIST Chemistry Reference: PF-3274167(900510-03-4)
• EPA Substance Registry System: PF-3274167(900510-03-4)

Safety Data

• Hazardous Substances Data: 900510-03-4(Hazardous Substances Data)

Usage

Description

PF-3274167 is an oxytocin receptor antagonist with high selectivity for the oxytocin receptor over the vasopressin receptors V1A and V2, exhibiting a Ki value of 9.5 nM.

Uses

Used in Pharmaceutical Industry:
PF-3274167 is used as a triazole oxytocin antagonist for the development of pharmaceuticals targeting the oxytocin receptor. Its high selectivity makes it a promising candidate for research and therapeutic applications related to the oxytocin receptor.
Used in Medical Imaging:
PF-3274167 is used as a PET radiotracer of oxytocin receptors, allowing for the visualization and study of oxytocin receptor distribution and function in the body. This application aids in understanding the role of oxytocin receptors in various physiological and pathological processes.

Upstream product

• 20605-41-8 methoxyacetic acid hydrazide 
• 900512-31-4 C₁₇H₁₇ClFN₃O₂S 

Relevant articles and documents

Triazole oxytocin antagonists: Identification of an aryloxyazetidine replacement for a biaryl substituent

A series of aryloxyazetidines, aryloxypyrrolidines and aryloxypiperidines were designed based on structural overlap with previously reported arylpyrazine Oxytocin antagonists. Similarly high levels of Oxytocin antagonism were achievable in these new serie

Substituted triazole derivatives as oxytocin antagonists

The present invention relates to substituted triazoles of formula (I), uses thereof, processes for the preparation thereof and compositions containing said compounds. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction.