900795-41-7Relevant articles and documents
Pyrrolotriazine-5-carboxylate ester inhibitors of EGFR and HER2 protein tyrosine kinases and a novel one-pot synthesis of C-4 subsitituted pyrrole-2,3-dicarboxylate diesters
Mastalerz, Harold,Gavai, Ashvinikumar V.,Fink, Brian,Struzynski, Charles,Tarrant, James,Vite, Gregory D.,Wong, Tai W.,Zhang, Guifen,Vyas, Dolatrai M.
, p. 528 - 533 (2007/10/03)
Pyrrolotriazines with an ester group at C-5 were prepared and evaluated as inhibitors of the EGFR and HER2 receptor tyrosine kinases, validated targets for cancer therapy. The C-5 ester (15) was at least as potent as its C-6 ester analogue (17), an exampl