9011-93-2

Basic information

• Product Name: LYSOSTAPHIN
• Synonyms: LYSOSTAPHIN;Lysostaphin from Staphylococcus staphylolyticus;lysostaphin from staphylococcus staphy-lolyticus;LYSOSTAPHIN ASEPTICALLY FILLED;LYSOSTAPHIN, STAPHYLOCOCCUS SIMULANS,*RE COMBINANT;LYSOSTAPHIN AFFINITY PURIFIED;LYSOSTAPHIN FROM STAPHYLOCOCCUS STAPHY-L OLYTICUS, ~1 U/MG;glycyl-glycine endopeptidase
• CAS NO: 9011-93-2
• Molecular Weight: 0
• EINECS: 812-596-7
• Mol File: 9011-93-2.mol
• Article Data: 0

Chemical Properties

• Appearance: slightly brown/powder
• Storage Temp.: −70°C
• Merck: 13,5659
• CAS DataBase Reference: LYSOSTAPHIN(CAS DataBase Reference)
• NIST Chemistry Reference: LYSOSTAPHIN(9011-93-2)
• EPA Substance Registry System: LYSOSTAPHIN(9011-93-2)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• RTECS: OL5985000
• F: 10-21
• Hazardous Substances Data: 9011-93-2(Hazardous Substances Data)

Usage

Description

Lysostaphin is a naturally occurring bacteriophage-encoded enzyme produced by Staphylococcus simulans. It exhibits potent antimicrobial activity against Staphylococcus aureus, a significant human pathogen responsible for various infections. Lysostaphin functions by hydrolyzing the cross-linkages in the peptidoglycan layer of the bacterial cell wall, leading to cell lysis and death. This unique property makes it a promising candidate for therapeutic applications, particularly against antibiotic-resistant strains of S. aureus.

Uses

Used in Pharmaceutical Industry:
Lysostaphin is used as an antimicrobial agent for targeting and eliminating Staphylococcus aureus infections. Its specificity for S. aureus makes it a valuable addition to the arsenal of antibiotics, especially in the context of increasing antibiotic resistance.
Used in Research Applications:
Lysostaphin is used as a research tool for studying the molecular mechanisms of bacterial cell wall synthesis and degradation. It has been employed in studies to assess the molecular cloning, sequencing, and expression of lytM, a unique autolytic gene of Staphylococcus aureus. Additionally, it has been utilized in sequence analysis of a Staphylococcus aureus gene encoding peptidoglycan hydrolase activity, providing insights into the bacterium's biology and potential therapeutic targets.
Used in Veterinary Medicine:
Lysostaphin has potential applications in veterinary medicine as a treatment for staphylococcal infections in animals. Its ability to target and kill S. aureus without causing harm to the host's normal flora makes it a promising candidate for use in veterinary therapeutics.
Used in Food Safety:
Lysostaphin can be employed in the food industry as a biopreservative to control the growth of Staphylococcus aureus and other spoilage-causing bacteria. Its antimicrobial properties can help maintain the safety and quality of food products, reducing the risk of foodborne illnesses.

Biochem/physiol Actions

Lysostaphin is a zinc endopeptidase with a molecular weight of approximately 25 kDa. Because lysostaphin cleaves the polyglycine cross-links in the peptidoglycan layer of the cell wall of Staphylococcus species it has been found useful for cell lysis and also as a potential anti-microbial therapeutic. pH Optimum for activity: ~7.5