90145-12-3Relevant articles and documents
Stereoselective synthesis of (6S) and (6R)-5,6-dihydro-6-[(2R)-2-hydroxy-6-phenylhexyl]-2H-pyran-2-one and their cytotoxic activity against cancer cell lines
Narasimhulu, Manchala,Krishna, Arepalli Sai,Rao, Janapala Venkateswara,Venkateswarlu, Yenamandra
experimental part, p. 2989 - 2994 (2009/06/20)
Stereoselective total synthesis of α,β-unsaturated lactone (1a), isolated from Ravensara crassifolia, has been achieved efficiently starting from chiral 2,3-O-isopropylidene-d-glyceraldehyde (3) followed by asymmetric allylation and ring-closing metathesi
An azido-functionalized isocarbacyclin analogue acting as an efficient photoaffinity probe for a prostacyclin receptor
Suzuki, Masaaki,Koyano, Hiroshi,Noyori, Ryoji,Hashimoto, Hitoshi,Negishi, Manabu,Ichikawa, Atsushi,Ito, Seiji
, p. 2635 - 2658 (2007/10/02)
A stable prostacyclin analogue, (15S)-18c, having an azidophenyl group as a photoaffinity labeling functionality has been synthesized. This compound has a sufficiently high affinity to the prostacyclin receptor protein in mastocytoma P-815 cells, exhibiting an IC50 value of 3 nM for the replacement of iloprost bound to the receptor protein. A photoaffinity probe compound, [3H]-(15S)-18c, is obtainable by reduction of the ketone 16c with [3H]NaBH4 - CeCl3 followed by alkaline hydrolysis of the methyl ester.