9025-82-5

Basic information

• Product Name: PHOSPHODIESTERASE I
• Synonyms: EC 3.1.4.1 TYPE IV;EC 3.1.4.1 TYPE V;EC 3.1.4.1 TYPE VI;EC 3.1.4.1;IUB: 3.1.4.1;5'-EXONUCLEASE;5'-EXONUCLEASE TYPE IV;5'-EXONUCLEASE TYPE V
• CAS NO: 9025-82-5
• Molecular Formula: NULL
• Molecular Weight: 0
• EINECS: 232-806-5
• Mol File: 9025-82-5.mol
• Article Data: 0

Chemical Properties

• Appearance: /crude dried venom
• Storage Temp.: −20°C
• CAS DataBase Reference: PHOSPHODIESTERASE I(CAS DataBase Reference)
• NIST Chemistry Reference: PHOSPHODIESTERASE I(9025-82-5)
• EPA Substance Registry System: PHOSPHODIESTERASE I(9025-82-5)

Safety Data

• Hazard Codes: T+
• Statements: 26/27/28
• Safety Statements: 36/37/39-45
• RIDADR: 2811
• WGK Germany: 3
• RTECS: SZ5999500
• HazardClass: 6.1(a)
• PackingGroup: II
• Hazardous Substances Data: 9025-82-5(Hazardous Substances Data)

Usage

Description

Phosphodiesterase I, a type of phosphodiesterase (PDE) enzyme, is a membrane-bound glycoprotein that catalyzes the hydrolysis of various nucleotide polyphosphates, specifically breaking phosphodiester bonds. This enzyme plays a crucial role in the regulation of cellular processes and signal transduction pathways.

Uses

Used in Research and Diagnostic Applications:
Phosphodiesterase I is used as a research tool in phosphodiesterase activation assays for the hydrolysis of AMP (adenosine monophosphate). This application aids in understanding the enzyme's function and its role in various biological processes.
Used in Biochemistry and Molecular Biology:
Product P3243, derived from Crotalus adamanteus venom, is a purified form of Phosphodiesterase I that has been utilized to hydrolyze tRNA with wyosine derivatives into mononucleosides. This application is valuable for studying the structure and function of tRNA and its modifications.
Used in Pharmaceutical and Venom Research:
Product P3134 is a crude, dried form of Crotalus adamanteus venom that contains Phosphodiesterase I. This product is used in the development of pharmaceuticals and for research purposes, particularly in understanding the properties and effects of venom-derived enzymes.

Biochem/physiol Actions

Phosphodiesterase I breaks phosphodiester bonds and catalyzes the hydrolysis of various nucleotide polyphosphates. Phosphodiesterase I is released from eucaryotic plasma membranes by phosphatidylinositol-specific phospholipase C.