902525-96-6Relevant articles and documents
New chiral building blocks from acetovanillone using lipase A and B from Candida antarctica
Fuglseth, Erik,Anthonsen, Thorleif,Hoff, Bard Helge
, p. 1290 - 1295 (2006)
Acetovanillone has been used as the starting material for the synthesis of a series of secondary alcohols, which were resolved by lipase catalyzed esterification. 1-(4-Benzyloxy-3-methoxyphenyl)ethanol was efficiently resolved using immobilized lipase B from Candida antarctica (Novozym 435, CAL-B), whereas immobilized lipase A from C. antarctica (Novozym 735, CAL-A) was the lipase of choice for the resolution of the corresponding 2-bromo- and 2-chloro-derivatives. The enantioenriched alcohols are new building blocks for potential use in the synthesis of bioactive compounds.