9026-43-1

Basic information

• Product Name: CAM KINASE II
• Synonyms: CA2+/CALMODULIN KINASE II, RAT BRAIN;CA2+/CALMODULIN-DEPENDENT PROTEIN KINASE II;CA2+/CALMODULIN KINASE II;CA2+/CALMODULIN KINASE II, ALPHA-SUBUNIT, RAT, RECOMBINANT;CAM KINASE II;EC 2.7.1.123;PROTEIN KINASE, 3':5'-CYCLIC AMP*DEPENDE NT FROM RAB;PROTEIN KINASE, 3':5'-CYCLIC AMP*DEPENDE NT FROM BOV
• CAS NO: 9026-43-1
• Molecular Formula: Ca
• Molecular Weight: 0
• EINECS: 283-495-8
• Mol File: 9026-43-1.mol
• Article Data: 0

Chemical Properties

• Appearance: /buffered aqueous glycerol solution
• Storage Temp.: −70°C
• Water Solubility: buffered aqueous glycerol solution
• CAS DataBase Reference: CAM KINASE II(CAS DataBase Reference)
• NIST Chemistry Reference: CAM KINASE II(9026-43-1)
• EPA Substance Registry System: CAM KINASE II(9026-43-1)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 9026-43-1(Hazardous Substances Data)

Usage

Description

CAM KINASE II, also known as Calcium/calmodulin-dependent protein kinase II, is a multifunctional serine/threonine kinase that plays a crucial role in various cellular processes, including signal transduction, synaptic plasticity, and learning and memory. It is activated by the binding of calcium/calmodulin complex, which leads to its autophosphorylation and subsequent activation of downstream signaling pathways.
Source:
CAM KINASE II is widely expressed in various tissues and cell types, with high levels found in the brain, heart, and skeletal muscle.
Production Methods:
The production of CAM KINASE II typically involves recombinant DNA technology, where the gene encoding the enzyme is inserted into a suitable expression system, such as bacteria or yeast, to produce the protein in large quantities.

Uses

Used in Research Applications:
CAM KINASE II is used as a research tool for studying its role in various cellular processes and signaling pathways. It is employed in various experimental setups, such as enzyme assays, immunoprecipitation, and immunofluorescence staining, to investigate its function and regulation.
Used in Drug Discovery and Development:
CAM KINASE II is a potential therapeutic target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease, as well as cardiovascular diseases. It is used in drug screening and development to identify small molecule inhibitors or activators that can modulate its activity and potentially treat these diseases.
Used in Diagnostic Applications:
CAM KINASE II can be used as a biomarker for certain diseases, such as cancer, where its expression levels may be altered. It can be employed in diagnostic assays, such as immunoassays or molecular diagnostics, to detect and monitor the presence of the enzyme in biological samples.
Used in Education and Training:
CAM KINASE II can be used as a teaching tool in educational and training programs to help students and researchers understand the structure, function, and regulation of this important enzyme. It can be employed in laboratory exercises, lectures, and workshops to provide hands-on experience and enhance learning.

Biochem/physiol Actions

Protein Kinase A (PKA) inhibits hormone-sensitive lipase translocation from cytosol to storage droplets and blocks lipolysis. It regulates apoptosis, mitochondrial respiration and ATP synthesis. PKA is modulated by protease calpain.