9027-13-8

Basic information

• Product Name: crotonase
• Synonyms: crotonase
• CAS NO: 9027-13-8
• Molecular Weight: 0
• Mol File: 9027-13-8.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: crotonase(CAS DataBase Reference)
• NIST Chemistry Reference: crotonase(9027-13-8)
• EPA Substance Registry System: crotonase(9027-13-8)

Safety Data

• Hazardous Substances Data: 9027-13-8(Hazardous Substances Data)

Usage

Description

Crotonase, also known as 2-enoyl-CoA hydratase, is an enzyme that plays a vital role in fatty acid metabolism. It catalyzes the hydration of crotonyl-CoA to form beta-hydroxybutyryl-CoA, an essential step in the breakdown of fatty acids for energy production. Crotonase is crucial for the beta-oxidation pathway, which is the primary process for utilizing fatty acids as a source of ATP in the body. Deficiencies in crotonase activity can lead to metabolic disorders such as Crotonase deficiency, resulting in symptoms like developmental delays, seizures, and neurologic problems. Understanding the structure and function of crotonase is important for developing treatments for these metabolic disorders and for gaining insights into the regulation of fatty acid metabolism.

Uses

Crotonase is used as a key enzyme in the beta-oxidation pathway for the breakdown of fatty acids to produce ATP in the body. This process is essential for energy production, particularly during periods of fasting or prolonged exercise when glucose levels are low.
In the field of metabolic research, crotonase is used as a subject of study to understand the regulation of fatty acid metabolism and the development of treatments for metabolic disorders related to crotonase deficiency. This includes investigating the enzyme's structure, function, and potential therapeutic targets for intervention.
Additionally, crotonase may be used in the development of diagnostic tools and tests to identify and monitor individuals with crotonase deficiency or other related metabolic disorders, helping to improve early detection and treatment outcomes.