902836-20-8

Basic information

• Product Name: 3-M-TOLYLOXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: 3-M-TOLYLOXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;TERT-BUTYL 3-(M-TOLYLOXY)PIPERIDINE-1-CARBOXYLATE;NNJZUDMDBWMSQB-UHFFFAOYSA-N
• CAS NO: 902836-20-8
• Molecular Formula: C17H25NO3
• Molecular Weight: 291.39
• Mol File: 902836-20-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-M-TOLYLOXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-M-TOLYLOXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(902836-20-8)
• EPA Substance Registry System: 3-M-TOLYLOXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(902836-20-8)

Safety Data

• Hazardous Substances Data: 902836-20-8(Hazardous Substances Data)

Upstream product

• 404577-34-0 (R)-3-methanesulfonyloxy-piperidine-1-carboxylic acid tert-butyl ester 
• 108-39-4 3-methyl-phenol 
• 940890-90-4 (S)-3-methanesulfonyloxy-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Convenient preparation of optically pure 3-aryloxy-pyrrolidines

Chiral 3-methanesulfonyl-1-Boc-pyrrolidine and piperidine were reacted with sodium phenolates, resulting in a mixture of displacement and elimination products. Following carbamate deprotection and pH adjustment, the 3-pyrroline and tetrahydropyridine by-products resulting from elimination were easily removed through aqueous partitioning and/or concentration. Although the pyrrolidines were formed with a high degree of optical purity, slight racemization was observed for the piperidine case because elevated temperatures were required to effect displacement. Copyright Taylor & Francis Group, LLC.