9029-12-3

Basic information

• Product Name: GLDH
• Synonyms: dehydrogenase,glutamate(nicotinamideadeninedinucleotide(phosphate));GLDH;GLUTAMATE DEHYDROGENASE, BOVINE;GLUTAMATE DEHYDROGENASE (BOVINE LIVER);glutamate dehydrogenase F. bovine liver;L-GLUTAMIC DEHYDROGENASE TYPE II*FROM BO VINE LIVER;GLUTAMATE DEHYDROGENASE F. BOVINE LIVER, LYO.,STAB.,>10U/MG;L-GLUTAMIC DEHYDROGENASE TYPE III*FROM B OVINE LIVER
• CAS NO: 9029-12-3
• Molecular Weight: 0
• EINECS: 232-848-4
• Mol File: 9029-12-3.mol
• Article Data: 0

Chemical Properties

• Appearance: amber/solution (viscous)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: GLDH(CAS DataBase Reference)
• NIST Chemistry Reference: GLDH(9029-12-3)
• EPA Substance Registry System: GLDH(9029-12-3)

Safety Data

• WGK Germany: 3
• F: 3-10
• Hazardous Substances Data: 9029-12-3(Hazardous Substances Data)

Usage

Description

GLDH, also known as L-Glutamic Dehydrogenase, is an enzyme that plays a crucial role in the metabolism of glutamate, an important amino acid in the body. It catalyzes the reversible conversion of isocitrate into alpha-ketoglutarate and carbon dioxide, which is essential for maintaining the balance of glutamate levels in the body.

Uses

Used in Biochemical Research:
GLDH is used as a research tool for studying the metabolism of glutamate and its role in various biological processes. It helps researchers understand the mechanisms of glutamate production and regulation, which can be useful in developing treatments for neurological disorders and other conditions related to glutamate imbalances.
Used in Clinical Diagnostics:
GLDH is used as a biomarker for various medical conditions, including liver diseases, muscle disorders, and certain types of cancer. Measuring GLDH levels in blood or other biological samples can help diagnose and monitor the progression of these diseases, as well as assess the effectiveness of treatments.
Used in Pharmaceutical Development:
GLDH is used in the development of drugs targeting the metabolism of glutamate. By modulating the activity of GLDH, researchers can develop therapeutic agents that can help restore glutamate balance in the body, potentially leading to the treatment of neurological disorders and other conditions associated with glutamate dysregulation.
Used in Food Industry:
GLDH can be used in the food industry as a catalyst for the production of glutamate, which is a key component of monosodium glutamate (MSG), a widely used flavor enhancer. By optimizing the conversion of isocitrate to alpha-ketoglutarate, GLDH can improve the efficiency of glutamate production, leading to cost savings and increased product quality.
Used in Environmental Applications:
GLDH can be employed in bioremediation processes to break down pollutants containing glutamate or related compounds. By catalyzing the conversion of these compounds into less harmful substances, GLDH can contribute to the development of sustainable and eco-friendly solutions for environmental pollution control.

Biochem/physiol Actions

Mammalian forms of this enzyme, including this bovine form, can use either NADP(H) or NAD(H) as coenzymes. L-glutamic dehydrogenase plays a unique role in mammalian metabolism. The reverse reaction catalyzed by this enzyme is the only pathway by which ammonia can become bound to the α-carbon atom of an α-carboxylic acid and thus, is the only source of de novo amino acid synthesis in mammalian species. The bovine enzyme is characterized by three sets of properties: It has a reversible concentration-dependent association, producing higher molecular weight forms.Forms tight enzyme-reduced coenzyme-substrate ternary complexes whose rates of dissociation modulate the steady-state reaction rates.Exhibits a wide variety of effects from the binding of any of a number of nucleotide modifiers.L-glutamic dehydrogenase catalyzes the conversion of glutamate to α-ketoglutarate.