90290-30-5

Basic information

• Product Name: 1-((2S,5S)-2,5-Bis-methoxymethoxymethyl-pyrrolidin-1-yl)-3-phenyl-propan-1-one
• Synonyms: 1-((2S,5S)-2,5-Bis-methoxymethoxymethyl-pyrrolidin-1-yl)-3-phenyl-propan-1-one
• CAS NO: 90290-30-5
• Molecular Weight: 351.443
• Mol File: 90290-30-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-((2S,5S)-2,5-Bis-methoxymethoxymethyl-pyrrolidin-1-yl)-3-phenyl-propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-((2S,5S)-2,5-Bis-methoxymethoxymethyl-pyrrolidin-1-yl)-3-phenyl-propan-1-one(90290-30-5)
• EPA Substance Registry System: 1-((2S,5S)-2,5-Bis-methoxymethoxymethyl-pyrrolidin-1-yl)-3-phenyl-propan-1-one(90290-30-5)

Safety Data

• Hazardous Substances Data: 90290-30-5(Hazardous Substances Data)

Upstream product

• 90290-04-3 trans-N-benzyl-2,5-bis(ethoxycarbonyl)pyrrolidine 
• 93621-95-5 (2S,5S)-bis(methoxymethoxymethyl)pyrrolidine 

Downstream Products

• 96424-29-2 (2S,3R)-2-Benzyl-1-((2S,5S)-2,5-bis-methoxymethoxymethyl-pyrrolidin-1-yl)-3-hydroxy-4-methyl-pentan-1-one 
• 90290-34-9 (R)-1-((2S,5S)-2,5-Bis-methoxymethoxymethyl-pyrrolidin-1-yl)-2-methyl-3-phenyl-propan-1-one 
• 96424-23-6 (S)-2-Benzyl-1-((2S,5S)-2,5-bis-methoxymethoxymethyl-pyrrolidin-1-yl)-4-methyl-pentane-1,3-dione 

Relevant articles and documents

ASYMMETRIC ALKYLATION OF CARBOXYAMIDES BY USING trans-2,5-DISUBSTITUTED PYRROLIDINES AS CHIRAL AUXILIARIES

trans-2,5-Bis(methoxymethyl)- and trans-2,5-bis(methoxymethoxymethyl)pyrrolidines proved to be excellent chiral auxiliaries for the asymmetric alkylation of the corresponding carboxyamide enolates giving good chemical yield and high stereoselectivity (invariably over 95percent de), with remarkable flexibility to substrates and reaction conditions.