90293-27-9

Basic information

• Product Name: L-Leucine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-a-glutamyl]-, bis(phenylmethyl) ester
• CAS NO: 90293-27-9
• Molecular Formula: C30H40N2O7
• Molecular Weight: 540.657
• Mol File: 90293-27-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-Leucine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-a-glutamyl]-, bis(phenylmethyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Leucine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-a-glutamyl]-, bis(phenylmethyl) ester(90293-27-9)
• EPA Substance Registry System: L-Leucine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-a-glutamyl]-, bis(phenylmethyl) ester(90293-27-9)

Safety Data

• Hazardous Substances Data: 90293-27-9(Hazardous Substances Data)

Upstream product

• 13574-13-5 Boc-Glu(OBzl)-OH 
• 2462-35-3 L-leucine benzyl ester hydrochloride 

Downstream Products

• 90293-28-0 (S)-2-[(S)-4-Benzyloxycarbonyl-2-((S)-3-benzyloxycarbonyl-2-tert-butoxycarbonylamino-propionylamino)-butyrylamino]-4-methyl-pentanoic acid benzyl ester 
• 155521-27-0 H-Tyr-Lys-Asp-Glu-Leu-OH 
• 5893-78-7 (S)-2-((S)-2-Amino-4-benzyloxycarbonyl-butyrylamino)-4-methyl-pentanoic acid benzyl ester 

Relevant articles and documents

Synthesis of oligonucleotide-peptide conjugates containing a KDEL signal sequence

An improved method of preparation of oligonucleotide-peptide conjugates is described. An oligopeptide containing α and ε-aminogroups is mainly substituted at its α-NH2 end by ε-maleimidocaproic acid-N-hydroxysuccinimide ester at pH 6.5 for 1 h. The N(α)-maleimidocaproyl-peptide derivative, purified by HPLC, reacts with the thiol group of an oligonucleotide in a 82% yield at pH 7.2. The thiol group is generated in situ by the action of tris(carboxyethyl)phosphine on an oligonucleotide bearing a disulfide bridge.