90296-07-4

Basic information

• Product Name: (2,3-dimethoxyphenoxy)acetic acid
• Synonyms: acetic acid, 2-(2,3-dimethoxyphenoxy)-
• CAS NO: 90296-07-4
• Molecular Formula: C₁₀H₁₂O₅
• Molecular Weight: 212.1993
• Mol File: 90296-07-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 332.2°C at 760 mmHg
• Flash Point: 128.8°C
• Density: 1.229g/cm³
• Vapor Pressure: 5.9E-05mmHg at 25°C
• Refractive Index: 1.52
• CAS DataBase Reference: (2,3-dimethoxyphenoxy)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2,3-dimethoxyphenoxy)acetic acid(90296-07-4)
• EPA Substance Registry System: (2,3-dimethoxyphenoxy)acetic acid(90296-07-4)

Safety Data

• Hazardous Substances Data: 90296-07-4(Hazardous Substances Data)

Usage

Description

(2,3-dimethoxyphenoxy)acetic acid is a chemical compound that consists of a phenoxyacetic acid group, with two methoxy (CH3-O-) groups attached to the 2 and 3 positions of the phenyl ring. It is commonly used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds.

Uses

Used in Pharmaceutical Industry:
(2,3-dimethoxyphenoxy)acetic acid is used as an intermediate for the synthesis of various pharmaceuticals for its potential anti-inflammatory and antioxidant properties, and it may also have applications in the development of new drugs for various medical conditions.
Used in Agrochemical Industry:
(2,3-dimethoxyphenoxy)acetic acid is used as an intermediate for the synthesis of various agrochemicals.
Used in Organic Synthesis:
(2,3-dimethoxyphenoxy)acetic acid is used as a building block in organic synthesis.
Used in Chemical Reactions:
(2,3-dimethoxyphenoxy)acetic acid is used as a reagent in chemical reactions.
Overall, (2,3-dimethoxyphenoxy)acetic acid has a wide range of potential uses in various industrial and scientific applications.

Upstream product

• 5150-42-5 2,3-dimethoxyphenol 
• 79-11-8 chloroacetic acid 
• 79-08-3 bromoacetic acid 
• 861085-96-3 ethyl (2,3-dimethoxyphenoxy)acetate 

Downstream Products

• 861085-96-3 ethyl (2,3-dimethoxyphenoxy)acetate 
• 858835-98-0 1-(2,3-dimethoxy-phenoxy)-3-(3,4-dimethoxy-phenyl)-acetone 
• 857808-86-7 2-(2,3-dimethoxy-phenoxymethyl)-3-(3,4-dimethoxy-phenyl)-2-hydroxy-propionitrile 
• 857816-57-0 4-(2,3-dimethoxy-phenoxy)-2-(3,4-dimethoxy-phenyl)-acetoacetonitrile 
• 857816-88-7 4-(2,3-dimethoxy-phenoxy)-2-(3,4-dimethoxy-phenyl)-acetoacetic acid amide 

Relevant articles and documents

6-Methoxy-7-benzofuranoxy and 6-methoxy-7-indolyloxy analogues of 2-[2-(2,6-Dimethoxyphenoxy)ethyl]aminomethyl-1,4-benzodioxane (WB4101):1 Discovery of a potent and selective α1D-adrenoceptor antagonist

Previous results have shown that replacement of one of the two o-methoxy groups at the phenoxy residue of the potent, but not subtype-selective, α1-AR antagonist (S)-WB4101 [(S)-1] by phenyl, or by ortho,meta-fused cyclohexane, or especially by ortho,meta-fused benzene preferentially elicits α1D-AR antagonist affinity. Such observations inspired the design of four new analogues of 1 bearing, in lieu of the 2,6-dimethoxyphenoxy residue, a 6-methoxy-substituted 7-benzofuranoxy or 7-indolyloxy group or, alternatively, their corresponding 2,3-dihydro form. Of these new compounds, which maintain, rigidified, the characteristic ortho heterodisubstituted phenoxy substructure of 1, the S enantiomer of the dihydrobenzofuranoxy derivative exhibited the highest α1D-AR antagonist affinity (pA2 9.58) with significant α1D/ α1A and α1D/α1B selectivity. In addition, compared both to α1D-AR antagonists structurally related to 1 and to the well-known α1D-AR antagonist BMY7378, this derivative had modest 5-HT1A affinity and neutral α1-AR antagonist behavior.