90301-68-1

Basic information

• Product Name: 5-(2-CHLOROETHYL)URACIL
• Synonyms: 5-(2-CHLOROETHYL)URACIL;2,4(1H,3H)-Pyrimidinedione, 5-(2-chloroethyl)-
• CAS NO: 90301-68-1
• Molecular Formula: C6H7ClN2O2
• Molecular Weight: 174.58498
• Mol File: 90301-68-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(2-CHLOROETHYL)URACIL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-CHLOROETHYL)URACIL(90301-68-1)
• EPA Substance Registry System: 5-(2-CHLOROETHYL)URACIL(90301-68-1)

Safety Data

• Hazardous Substances Data: 90301-68-1(Hazardous Substances Data)

Upstream product

• 23956-12-9 5-(2-hydroxyethyl)-uracil 
• 37107-74-7 5,6-dihydrofuro<2,3-d>pyrimidin-2(3H)-one 

Downstream Products

• 90301-69-2 5-(2-chloroethyl)-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-1H,3H-pyrimidine-2,4-dione 
• 90301-63-6 5-(2-chloroethyl)-1-(2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl)-1H,3H-pyrimidine-2,4-dione 
• 90301-59-0 5-(2-chloroethyl)-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1H,3H-pyrimidine-2,4-dione 
• 90301-73-8 5-(2-chloroethyl)-1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-1H,3H-pyrimidine-2,4-dione 
• 108034-57-7 1-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-(2-chloroethyl)-1H,3H-pyrimidine-2,4-dione 

Relevant articles and documents

Nucleoside analogues

Nucleoside analogues containing the degenerate base analogue P and derivatives thereof are provided with reporter moieties preferably comprising signal moieties. The nucleoside analogues are useful for labeling DNA or RNA or for incorporating in oligonucleotides.

Preparation of thionucleosides

The invention relates to the preparation of homochiral thiolactones which have application in the synthesis of 3?- and 4?- thionucleosides. Substituents on the thiolactone can be used to influence the configuration of the C-1? position in the final nucleoside. Configuration at the C-4? position is controlled by use of the appropriate homochiral glycidol as starting material in the synthesis of the thiolactone. This process also offers the possibility of introducing substituents diastereoselectively in the C-2? and C-3? positions.