903518-34-3

Basic information

• Product Name: cyclo-[Arg(Pbf)-Gly-Asp(OtBu)-D-Tyr(OtBu)-Lys-H]
• Synonyms: cyclo-[Arg(Pbf)-Gly-Asp(OtBu)-D-Tyr(OtBu)-Lys-H]
• CAS NO: 903518-34-3
• Molecular Weight: 984.227
• Mol File: 903518-34-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: cyclo-[Arg(Pbf)-Gly-Asp(OtBu)-D-Tyr(OtBu)-Lys-H](CAS DataBase Reference)
• NIST Chemistry Reference: cyclo-[Arg(Pbf)-Gly-Asp(OtBu)-D-Tyr(OtBu)-Lys-H](903518-34-3)
• EPA Substance Registry System: cyclo-[Arg(Pbf)-Gly-Asp(OtBu)-D-Tyr(OtBu)-Lys-H](903518-34-3)

Safety Data

• Hazardous Substances Data: 903518-34-3(Hazardous Substances Data)

Upstream product

• 187618-60-6 Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine 
• 118488-18-9 Fmoc-D-Tyr(O-tBu)-OH 
• 86060-82-4 Fmoc-Lys(Z)-OH 
• 903518-33-2 C₅₆H₈₁N₉O₁₄S 

Relevant articles and documents

[68ga]ga-dfo-c(Rgdyk): Synthesis and evaluation of its potential for tumor imaging in mice

, Abstract: Angiogenesis has a pivotal role in tumor growth and the metastatic process. Molecular imaging was shown to be useful for imaging of tumor-induced angiogenesis. A great variety of radiolabeled peptides have been developed to target αvβ3 integrin, a target structure involved in the tumor-induced angiogenic process. The presented study aimed to synthesize deferoxamine (DFO)-based c(RGD) peptide conjugate for radiolabeling with gallium-68 and perform its basic preclinical characterization including testing of its tumor-imaging potential. DFO-c(RGDyK) was labeled with gallium-68 with high radiochemical purity. In vitro characterization including stability, partition co-efficient, protein binding determination, tumor cell uptake assays, and ex vivo biodistribution as well as PET/CT imaging was performed. [68Ga]Ga-DFO-c(RGDyK) showed hydrophilic properties, high stability in PBS and human serum, and specific uptake in U-87 MG and M21 tumor cell lines in vitro and in vivo. We have shown here that [68Ga]Ga-DFO-c(RGDyK) can be used for αvβ3 integrin targeting, allowing imaging of tumor-induced angiogenesis by positron emission tomography.

Radio-analytical determination of the coating efficiency of cyclic RGD peptides

Coating of artificial surfaces with ROD (=arginine-glycine-aspartate) peptides to enhance cell adhesion is an ongoing issue. Thereby, the physiological adhesion process to the extra-cellular matrix (ECM) is mimicked by the peptide coating, leading to a st