903522-13-4

Basic information

• Product Name: 6-chloro-4'-(2,6-difluorobenzamido)-[1,1'-biphenyl]-3-carboxylic acid
• Synonyms: 6-chloro-4'-(2,6-difluorobenzamido)-[1,1'-biphenyl]-3-carboxylic acid
• CAS NO: 903522-13-4
• Molecular Weight: 387.77
• Mol File: 903522-13-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6-chloro-4'-(2,6-difluorobenzamido)-[1,1'-biphenyl]-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-4'-(2,6-difluorobenzamido)-[1,1'-biphenyl]-3-carboxylic acid(903522-13-4)
• EPA Substance Registry System: 6-chloro-4'-(2,6-difluorobenzamido)-[1,1'-biphenyl]-3-carboxylic acid(903522-13-4)

Safety Data

• Hazardous Substances Data: 903522-13-4(Hazardous Substances Data)

Upstream product

• 903522-11-2 2,6-difluoro-N-(4-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)benzamide 
• 42860-04-8 4-chloro-3-iodobenzoic acid 

Relevant articles and documents

Design, synthesis and phenotypic evaluation of N-biaryl amides for IL-17A suppression

A series of N-biaryl amides for Th17 cell phenotypic screening were designed and quickly prepared by microwave-assisted solid-phase organic synthesis. The structure-activity relationship of the three regions of the amides was explored and potent small molecular inhibitors that suppress IL-17A production in mouse Th17 cells were identified. Compound 6h showed excellent suppression of IL-17A with an IC50 of 13 nM, which can be employed as a chemical tool for target identification and Th17 cell-related biological studies.