903897-76-7

Basic information

• Product Name: 2-amino-N-(3,5-bis-trifluoromethyl-benzyl)-2-(4-fluoro-phenyl)-acetamide
• CAS NO: 903897-76-7
• Molecular Weight: 394.292
• Mol File: 903897-76-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-amino-N-(3,5-bis-trifluoromethyl-benzyl)-2-(4-fluoro-phenyl)-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-N-(3,5-bis-trifluoromethyl-benzyl)-2-(4-fluoro-phenyl)-acetamide(903897-76-7)
• EPA Substance Registry System: 2-amino-N-(3,5-bis-trifluoromethyl-benzyl)-2-(4-fluoro-phenyl)-acetamide(903897-76-7)

Safety Data

• Hazardous Substances Data: 903897-76-7(Hazardous Substances Data)

Upstream product

• 142186-36-5 (S)-2-((tert-butoxycarbonyl)amino)-2-(4-fluorophenyl)acetic acid 
• 85068-29-7 3,5-bis-trifluoromethylbenzylamine 

Relevant articles and documents

Discovery of 3,5-bis(trifluoromethyl)benzyl l-arylglycinamide based potent CCR2 antagonists

Systematic modification of a screening lead yielded a class of potent glycinamide based CCR2 antagonists. The best compound (55, (2S)-N-[3,5-bis(trifluoromethyl)benzyl]-2-{[2-(1-piperidinyl)ethyl]amino}-2-(3-thienyl)acetamide) displayed good binding affinity (IC50 = 30 and 39 nM) toward human monocytes and CHO cell expressing human CCR2b, respectively. Functionally, it blocked MCP-1 (CCL2)-induced calcium mobilization (IC50 = 50 nM) and chemotaxis mediated through the CCR2 receptor (9.6 nM). It is selective against other chemokine receptors tested.