90390-02-6

Basic information

• Product Name: N-(4-methoxybenzyl)-N-propylamine
• Synonyms: N-(4-methoxybenzyl)-N-propylamine;(4-METHOXYBENZYL)PROPYLAMINE;N-(4-METHOXYPHENYLMETHYL)PROPYLAMINE;UKRORGSYN-BB BBV-075385;90389-69-8 (Hydrochloride);Aids107191;Aids-107191;Benzenemethanamine, 4-methoxy-N-propyl-
• CAS NO: 90390-02-6
• Molecular Formula: C₁₁H₁₇NO
• Molecular Weight: 179.2588
• Mol File: 90390-02-6.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 259.6°Cat760mmHg
• Flash Point: 105.4°C
• Appearance: /
• Density: 0.953g/cm³
• Vapor Pressure: 0.0128mmHg at 25°C
• Refractive Index: 1.5
• CAS DataBase Reference: N-(4-methoxybenzyl)-N-propylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methoxybenzyl)-N-propylamine(90390-02-6)
• EPA Substance Registry System: N-(4-methoxybenzyl)-N-propylamine(90390-02-6)

Safety Data

• Hazardous Substances Data: 90390-02-6(Hazardous Substances Data)

Usage

Description

N-(4-methoxybenzyl)-N-propylamine, also known as 4-Methoxybenzylpropylamine, is an organic compound characterized by its chemical formula C11H17NO. It presents as a pale yellow to brown liquid with a distinctive sweet odor. This versatile chemical is primarily utilized in the synthesis of pharmaceuticals and serves as an intermediate in the production of a variety of chemical compounds. It is recognized for its role as a precursor in the preparation of potential therapeutic agents, which have been investigated for their efficacy in treating a range of diseases. Furthermore, its pleasant aroma has found application in the fragrance and flavor industries. However, due to its potential to cause irritation to the eyes, skin, and respiratory system, careful handling is advised.

Uses

Used in Pharmaceutical Synthesis:
N-(4-methoxybenzyl)-N-propylamine is used as a precursor in the synthesis of pharmaceuticals for its ability to contribute to the development of potential therapeutic agents. It plays a crucial role in the preparation of compounds that are being studied for their medicinal properties and potential use in treating various diseases.
Used in Chemical Compound Production:
As an intermediate, N-(4-methoxybenzyl)-N-propylamine is utilized in the production of various chemical compounds, highlighting its importance in the chemical industry for creating a range of end products.
Used in Fragrance and Flavor Industry:
Leveraging its sweet odor, N-(4-methoxybenzyl)-N-propylamine is used as a component in the creation of fragrances and flavors, adding to the sensory experience of various consumer products.
Used in Research and Development:
In the scientific community, this compound is used in research and development for exploring its potential applications in medicine and other industries, given its unique chemical properties and reactivity.

InChI:InChI=1/C11H17NO/c1-3-8-12-9-10-4-6-11(13-2)7-5-10/h4-7,12H,3,8-9H2,1-2H3

Upstream product

• 16928-40-8 2,3,6,7-tetrahydro-2-(4-methoxylphenyl)-3-propylcyclo-penta[e][1,3]oxazin-4(5H)-one 
• 171414-19-0 N-(4-methoxybenzyl)-2-nitro-N-propylbenzenesulfonamide 
• 1027628-05-2 C₁₇H₂₀N₂O₅S 
• 107-10-8 propylamine 
• 123-11-5 4-methoxy-benzaldehyde 
• 71-23-8 propan-1-ol 
• 2393-23-9 4-methoxy-benzylamine 
• 171414-16-7 N-(4-methoxybenzyl)-2-nitro-N-(prop-2-yn-1-yl)benzenesulfonamide 
• 108-03-2 1-Nitropropane 
• 874-90-8 4-methoxybenzonitrile 

Downstream Products

• 123-11-5 4-methoxy-benzaldehyde 
• 7464-43-9 4-methoxy-N-n-propylbenzamide 

Relevant articles and documents

One-pot, chemoselective synthesis of secondary amines from aryl nitriles using a PdPt-Fe3O4nanoparticle catalyst

We have developed a new catalytic method for the one-pot, cascade synthesis of unsymmetrical secondary amines via the reductive amination of aryl nitriles with nitroalkanes using a PdPt-Fe3O4 nanoparticle (NP) catalyst. The use of a bimetallic catalyst resulted in enhanced reactivity and selectivity compared to that of either monometallic Pd-Fe3O4 or the Pt-Fe3O4 NP catalyst. Using this bimetallic catalytic system, we were successful in the synthesis of various unsymmetrical secondary amines under mild conditions. However, aryl nitriles containing an electron-donating substituent were rather resistant to the reductive amination, and when hexafluoroisopropanol (HFIP) was used as a co-solvent, the reaction selectivity and yield for unsymmetrical secondary amines increased dramatically. Using the catalyst system, one-pot, gram-scale synthesis of indole was possible from 2-nitrophenylacetonitrile. Due to the magnetic property of the Fe3O4 support, the bimetallic catalyst could easily be recycled using an external magnet at least four times.

Synthesis and biological activity of some novel substituted quinazoline derivatives

A new series of 4-N-(substituted benzyl)-2-phenyl-N-propylquinazolines were synthesized. The structures of the synthesized compounds were confirmed by IR, 1H NMR, 13C NMR and mass spectral analysis. All the synthesized compounds were screened for their analgesic and anti-inflammatory activity. Among the synthesized compounds 5c, 5h and 5o exhibited significant analgesic activity at 60 and 90 minutes reading, while compounds 5g, 5k and 5l exhibited significant anti-inflammatory activity at 3rd and 4th hr reading.

Secondary amine formation from reductive amination of carbonyl compounds promoted by lewis acid using the InCl3ZEt3SiH system

A robust and reliable method has been developed for reductive amination of primary amines with various aldehydes and ketones using Zn(ClO4) 2.6H20 as a catalyst. [In-H] generated in situ via a combination of InCl3 and Et3SiH is employed as an effective reducing system. A variety of secondary amines can be synthesized in a one-pot procedure in excellent yields.