90390-22-0

Basic information

• Product Name: N-(3,5-dichlorobenzyl)ethanamine
• Synonyms: Benzenemethanamine, 3,5-dichloro-N-ethyl-
• CAS NO: 90390-22-0
• Molecular Formula: C₉H₁₁Cl₂N
• Molecular Weight: 204.0963
• Mol File: 90390-22-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 258.7°C at 760 mmHg
• Flash Point: 110.3°C
• Density: 1.19g/cm³
• Vapor Pressure: 0.0135mmHg at 25°C
• Refractive Index: 1.54
• CAS DataBase Reference: N-(3,5-dichlorobenzyl)ethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3,5-dichlorobenzyl)ethanamine(90390-22-0)
• EPA Substance Registry System: N-(3,5-dichlorobenzyl)ethanamine(90390-22-0)

Safety Data

• Hazardous Substances Data: 90390-22-0(Hazardous Substances Data)

Upstream product

• 75692-67-0 [1-(3,5-Dichloro-phenyl)-meth-(E)-ylidene]-ethyl-amine 
• 10203-08-4 3,5-dichlorobenzaldehyde 
• 75-04-7 ethylamine 

Relevant articles and documents

Tertiary Amine Pyrazolones and Their Salts as Inhibitors of Mutant Superoxide Dismutase 1-Dependent Protein Aggregation for the Treatment of Amyotrophic Lateral Sclerosis

Pyrazolone derivatives have previously been found to be inhibitors of Cu/Zn superoxide dismutase 1 (SOD1)-dependent protein aggregation, which extended survival of an amyotrophic lateral sclerosis (ALS) mouse model. On the basis of ADME analysis, we describe herein a new series of tertiary amine-containing pyrazolones and their structure-activity relationships. Further conversion to the conjugate salts greatly improved their solubility. Phosphate compound 17 exhibited numerous benefits both to cellular activity and to CNS-related drug-like properties in vitro and in vivo, including microsomal stability, tolerated toxicity, and blood-brain barrier permeation. These results indicate that tertiary amine pyrazolones comprise a valuable class of ALS drug candidates.