90417-27-9

Basic information

• Product Name: 4-Hydroxy-8-methoxycinnoline
• Synonyms: 8-Methoxy-1H-cinnolin-4-one;8-METHOXYCINNOLIN-4-OL
• CAS NO: 90417-27-9
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.17
• Mol File: 90417-27-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Hydroxy-8-methoxycinnoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxy-8-methoxycinnoline(90417-27-9)
• EPA Substance Registry System: 4-Hydroxy-8-methoxycinnoline(90417-27-9)

Safety Data

• Hazardous Substances Data: 90417-27-9(Hazardous Substances Data)

Upstream product

• 90800-12-7 (2-methoxy-phenylhydrazono)-malonyl chloride 
• 42465-54-3 1-(2-amino-3-methoxyphenyl)ethanone 
• 15865-57-3 2-nitro-3-methoxybenzoyl chloride 
• 4920-80-3 3-methoxy-2-nitrobenzoic acid 
• 33852-43-6 1-(3-methoxy-2-nitrophenyl)ethanone 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 39061-72-8 2-acetyl-5-chloroaniline 
• 136290-47-6 2-[(tert-butoxycarbonyl)amino]-4-chlorobenzoic acid 
• 1198473-06-1 tert-butyl [5-chloro-2-[methoxy(methyl)carbamoyl]phenyl]carbamate 
• 1204652-83-4 tert-butyl (2-acetyl-5-chlorophenyl)carbamate 
• 3177-80-8 2-amino-3-methoxybenzoic acid 

Downstream Products

• 817209-48-6 4-chloro-8-methoxy-cinnoline 
• 1204652-09-4 3-[2-chloro-3-(trifluoromethyl)phenyl]-1-(2,4-difluorobenzyl)-8-methoxycinnolin-4(1H)-one 
• 33844-20-1 3-bromo-8-methoxy-1H-cinnolin-4-one 
• 1204652-86-7 3-Bromo-1-(2,4-difluorobenzyl)-8-methoxycinnolin-4(1H)-one 
• 1246921-14-1 N-(2-{3-[2-fluoro-3-(trifluoromethyl)phenyl]-8-methoxy-4-oxocinnolin-1(4H)-yl}ethyl)methanesulphonamide 

Relevant articles and documents

Novel 4-(1H-1,2,3-triazol-4-yl)methoxy)cinnolines as potent antibacterial agents: Synthesis and molecular docking study

A new series of cinnoline-1,2,3-triazole derivatives were designed and synthesized by adopting Cu(1) catalyzed regeoselective1,3-dipolar cycloaddition reaction of terminal alkyne and azide. The in vitro antibacterial activity of all these compounds revealed that compounds 9d, 10a, 10b, and 10c are more potent antibacterial agents. Among the series, compound 4-(3-(4-((cinnolin-4-yloxy)methyl)-1H-1,2,3-triazol-1-yl)propyl)morpholine (10b) exhibited the most potent antibacterial activity against all tested gram-positive and gram-negative bacterial strains. Furthermore, molecular docking studies were also performed to understand the binding interactions of the most active analogs 9d, 10a, 10b, and 10c with Elastase of Pseudomonas aeruginosa (PDB: 1U4G). The results indicated that these classes of compounds have potential antibacterial activity, especially the compound 10b may serve as a promising antibacterial lead compound that could be further optimized for the further development of antibacterial drugs.

SUBSTITUTED 1-BENZYL-CINNOLIN-4(1H)-ONE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF

The present invention is related to novel substituted 1-benzylcinnolin-4(1H)-one derivatives having affinity for cannabinoid CB2 receptors, their preparation and their therapeutic application.

Herbicidal 2 methyl-4-phosphinylcinnolinium hydroxide inner salts

Certain 2-methyl-4-phosphinylcinnolinium hydroxide inner salts, useful for controlling unwanted plants.