90445-44-6

Basic information

• Product Name: 3-O-TOLYL-3H-ISOBENZOFURAN-1-ONE
• Synonyms: 3-O-TOLYL-3H-ISOBENZOFURAN-1-ONE
• CAS NO: 90445-44-6
• Molecular Formula: C₁₅H₁₂O₂
• Molecular Weight: 224.25458
• Mol File: 90445-44-6.mol
• Article Data: 20

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-O-TOLYL-3H-ISOBENZOFURAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-O-TOLYL-3H-ISOBENZOFURAN-1-ONE(90445-44-6)
• EPA Substance Registry System: 3-O-TOLYL-3H-ISOBENZOFURAN-1-ONE(90445-44-6)

Safety Data

• Hazardous Substances Data: 90445-44-6(Hazardous Substances Data)

Upstream product

• 110876-06-7 2-o-Toluoyl-benzil 
• 1018-97-9 2,2'-dimethylbenzophenone 
• 108-88-3 toluene 
• 119-67-5 o-carboxybenzaldehyde 
• 932-31-0 ortho-tolylmagnesium bromide 
• 601-70-7 3,3-dichlorophthalide 
• 502924-05-2 2-methyl-2'-(4,4-dimethyl-1,3-oxazol-2-yl)diphenylmethyl alcohol 
• 21147-26-2 2-(2-methylbenzoyl)benzoic acid methyl ester 
• 529-20-4 2-methylphenyl aldehyde 
• 32664-13-4 2-(2-bromo-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole 
• 16419-60-6 2-Methylphenylboronic acid 
• 643-79-8 o-phthalic dicarboxaldehyde 
• 4122-56-9 methyl o-formylbenzoate 
• 7468-67-9 o-formylbenzonitrile 

Downstream Products

• 502924-03-0 2-carboxy-2'-methyldiphenylmethyl methylsulfide 

Relevant articles and documents

Access to Diarylmethanols by Wittig Rearrangement of ortho-, meta-, and para-Benzyloxy- N-Butylbenzamides

The N-butyl amide group, CONHBu, has been found to be an effective promoter of the [1,2]-Wittig rearrangement of aryl benzyl ethers and thus allow the two-step synthesis of isomerically pure substituted diarylmethanols starting from simple hydroxybenzoic acid derivatives. The method is compatible with a wide range of functional groups including methyl, methoxy, and fluoro, although not with nitro and, unexpectedly, is applicable to meta as well as ortho and para isomeric series.

Direct and selective synthesis of 3-arylphthalides via nickel-catalyzed aryl addition/intramolecular esterification

Herein we report a nickel-catalyzed aryl addition/intramolecular esterification in a cascade fashion. Under the combination of commercially available nickel precursor and tridentate ligand, the one pot protocol offers a direct, simple and regioselective approach to access 3-aryl phthalide derivatives from two readily available substrates with good efficiency, broad scope as well as satisfactory functional group compatibility.

Catalytic asymmetric synthesis of 3-aryl phthalides enabled by arylation-lactonization of 2-formylbenzoates

The catalytic asymmetric synthesis of 3-aryl phthalides is reported through a sequential asymmetric arylation-lactonization reaction. The reaction is enabled by a boron-zinc exchange to generate reactive arylating agents, which react with 2-formylbenzoates in the presence of a chiral amino naphthol ligand. The enantiodetermining step is the arylation of the aldehyde, which then undergoes a lactonization event to yield the corresponding phthalides in good yields and enantioselectivities.