9047-57-8

Basic information

• Product Name: CHONDROITIN AC LYASE
• Synonyms: EC 4.2.2.5;CHONDROITINASE AC;CHONDROITINASE AC 1;CHONDROITINASE AC 2;CHONDROITINASE AC I;CHONDROITINASE AC II;CHONDROITINASE AC-II LYASE;CHONDROITIN AC LYASE
• CAS NO: 9047-57-8
• Molecular Weight: 0
• Mol File: 9047-57-8.mol
• Article Data: 0

Chemical Properties

• Appearance: /lyophilized powder
• Storage Temp.: −20°C
• Solubility: 0.02 M phosphate buffer: soluble (pH 7.0)
• CAS DataBase Reference: CHONDROITIN AC LYASE(CAS DataBase Reference)
• NIST Chemistry Reference: CHONDROITIN AC LYASE(9047-57-8)
• EPA Substance Registry System: CHONDROITIN AC LYASE(9047-57-8)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 9047-57-8(Hazardous Substances Data)

Usage

Description

Chondroitinase AC lyase, also known as Chondroitin AC lyase, is an enzyme that catalyzes the degradation of chondroitin sulfate, a glycosaminoglycan found in the extracellular matrix of connective tissues. It specifically cleaves the glycosidic bond between N-acetylgalactosamine and glucuronic acid, resulting in the disaccharide units of chondroitin sulfate. This enzyme has gained significant attention in the field of glycobiology and has potential applications in various industries.

Uses

Used in Glycobiology Research:
Chondroitin AC lyase is used as a research tool for studying the structure, function, and metabolism of chondroitin sulfate. It helps in understanding the role of chondroitin sulfate in various biological processes and its involvement in various diseases.
Used in Quality Control of Dietary Supplements:
Chondroitinase AC lyase is used as a quality control agent for analyzing chondroitin sulfate in commercial samples such as dietary supplements. It helps in determining the purity, concentration, and authenticity of chondroitin sulfate present in these products, ensuring their safety and efficacy for consumers.
Used in Pharmaceutical Industry:
Chondroitin AC lyase has potential applications in the pharmaceutical industry for the development of drugs targeting chondroitin sulfate-related diseases. By degrading chondroitin sulfate, this enzyme can help in modulating the biological activities of this glycosaminoglycan, which may have therapeutic benefits in treating various disorders.
Used in Cosmetic Industry:
Chondroitin AC lyase can be used in the cosmetic industry for the development of skincare products targeting the extracellular matrix and its components, including chondroitin sulfate. By modulating the levels of chondroitin sulfate in the skin, this enzyme may contribute to improved skin health, elasticity, and appearance.

Biochem/physiol Actions

Chondroitinase AC from Flavobacterium heparinum is an enzyme that cleaves sulfated and non-sulfated polysaccharide chains with (1-4) linkages between hexosamines and glucuronic acid residues, by an elimination mechanism. The resulting oligosaccharide products are mainly disaccharides with unsaturated uronic acids. Chondroitinase AC specifically degrades chondroitin sulfates A and C, but not chondroitin sulfate B (dermatan sulfate).