904925-57-1Relevant articles and documents
A functionally orthogonal ligand-receptor pair created by targeting the allosteric mechanism of the thyroid hormone receptor
Hassan, A. Quamrul,Koh, John T.
, p. 8868 - 8874 (2007/10/03)
Nuclear receptors are ligand-dependent transcription factors that are of interest as potential tools to artificially regulate gene expression. Ligand binding induces a conformational change involving helix-12 which forms part of the dimerization interface