90503-16-5

Basic information

• Product Name: 2-[3-(benzyloxy)-2-hydroxypropyl]-1H-isoindole-1,3(2H)-dione
• CAS NO: 90503-16-5
• Molecular Formula: C₁₈H₁₇NO₄
• Molecular Weight: 311.3319
• Mol File: 90503-16-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 504.6°C at 760 mmHg
• Flash Point: 259°C
• Density: 1.307g/cm³
• Vapor Pressure: 5.27E-11mmHg at 25°C
• Refractive Index: 1.622
• CAS DataBase Reference: 2-[3-(benzyloxy)-2-hydroxypropyl]-1H-isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[3-(benzyloxy)-2-hydroxypropyl]-1H-isoindole-1,3(2H)-dione(90503-16-5)
• EPA Substance Registry System: 2-[3-(benzyloxy)-2-hydroxypropyl]-1H-isoindole-1,3(2H)-dione(90503-16-5)

Safety Data

• Hazardous Substances Data: 90503-16-5(Hazardous Substances Data)

Usage

Structure

Contains a benzyl group, hydroxypropyl group, and an isoindole-1,3(2H)-dione core structure

Derivative

It is a derivative of isoindole-1,3(2H)-dione, a common pharmacophore in medicinal chemistry

Potential pharmacological activities

Antitumor, anti-inflammatory, and neuroprotective properties

Research and development

The specific properties and potential applications have not been extensively documented, but may hold promise for further research and development in the field of medicinal chemistry

Upstream product

• 85-44-9 phthalic anhydride 
• 90503-15-4 (RS)-(3-benzyloxy-2-hydroxypropyl)amine 
• 5455-98-1 2-oxiranylmethylisoindole-1,3-dione 
• 100-51-6 benzyl alcohol 
• 1074-82-4 potassium phtalimide 
• 2930-05-4 Benzyloxymethyl-oxiran 
• 136918-14-4 phthalimide 

Downstream Products

• 90503-17-6 1-benzyloxy-2-chloromethoxy-3-phthaloylimidopropane 
• 90503-15-4 (RS)-(3-benzyloxy-2-hydroxypropyl)amine 
• 134580-97-5 5-(benzyloxymethyl)-oxazolidin-2-one 
• 158832-16-7 5-benzyloxymethyl-3-(4-bromobutyl)-2-oxazolidinone 
• 114894-52-9 5-benzyl-1-<(1'-phthalimidomethyl-2'-hydroxyethoxy)methyl>uracil 
• 114894-51-8 5-benzyl-1-<(1'-phthalimidomethyl-2'-hydroxyethoxy)methyl>-2-oxo-4-methoxypyrimidine 
• 114894-43-8 5-(3-benzyloxybenzyl)-1-<(1'-phthalimidomethyl-2'-benzyloxyethoxy)methyl>-2-oxo-4-methoxypyrimidine 
• 114894-44-9 5-(3'-hydroxybenzyl)-1-<(1'-phthalimidomethyl-2'-hydroxyethoxy)methyl>-2-oxo-4-methoxypyrimidine 
• 114894-50-7 5-benzyl-1-<(1'-phthalimidomethyl-2'-benzyloxyethoxy)methyl>-2-oxo-4-methoxypyrimidine 
• 114894-45-0 5-(3-benzyloxybenzyl)-1-<(1'-phthalimidomethyl-2'-hydroxyethoxy)methyl>-2-oxo-4-methoxypyrimidine 
• 114894-46-1 5-(3-benzyloxybenzyl)-1-<(1'-phthalimidomethyl-2'-hydroxyethoxy)methyl>uracil 

Relevant articles and documents

METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION

Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

Aminopolycarboxylic acids and derivatives thereof

There are provided chelating agents particularly useful for the preparation of diagnostic and therapeutic agents for magnetic resonance imaging, scintigraphy, ultrasound imaging, radiotherapy and heavy metal detoxification, said agents being compounds of formula I wherein n and m are 2, 3 or 4; and A, X, R1 and Z are as defined in the specification.

Aminopolycarboxylic acids and derivatives thereof

There are provided chelating agents particularly useful for the preparations of diagnostic and therapeutic agents for magnetic resonance imaging, scintigraphy, ultrasound imaging, radiotherapy and heavy metal detoxification, said agents being compounds of formula X--CHR1 --NZ--(CHR1)n --A--(CHR1)m --NZ--CHR1 --X wherein (each of the groups Z is a group --CHR1 X or the groups Z together are a group --(CHR1)q --A'--(CHR1)r --, where A' is an oxygen or sulphur atom or a group --N--Y; A is a group --N--Y or A--(CHR1)m -- represents a carbon-nitrogen bond or, when the groups Z together are a group --(CHR1)q --A'--(CHR1)r --, A may also represent an oxygen or sulphur atom; each Y, which may be the same or different, is a group --(CHR1)p --N(CHR1 X)2 or a group --CHR1 X; each X, which may be the same or different, is a carboxyl group or a derivative thereof or a group R1 ; each R1, which may be the same or different, is a hydrogen atom, a hydroxyalkyl group or an optionally hydroxylated alkoxy or alkoxyalkyl group; n, m, p, q and r are each 2, 3 or 4; with the provisos that at least two nitrogens carry a --CHR1 X moiety wherein X is a carboxyl group or a derivative thereof, that each --CHR1 X moiety is other than a methyl group, and that unless A' is oxygen or sulphur or A is N--(CHR1)p --N(CHR1 X)2 at least one R1 is other than hydrogen) and salts thereof.