905274-03-5

Basic information

• Product Name: Tert-Butyl2-(Trifluoromethyl)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate
• Synonyms: Tert-Butyl2-(Trifluoromethyl)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate;tert-butyl 2-(trifluoroMethyl)-5H,6H,7H-pyrrolo[3,4-d]pyriMidine-6-carboxylate;5,7-dihydro-2-(trifluoromethyl)-6H-Pyrrolo[3,4-d]pyrimidine-6-
• CAS NO: 905274-03-5
• Molecular Formula: C12H14F3N3O2
• Molecular Weight: 289.256
• Mol File: 905274-03-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 301.8°C at 760 mmHg
• Flash Point: 136.4°C
• Appearance: /
• Density: 1.334g/cm³
• Vapor Pressure: 0.00103mmHg at 25°C
• Refractive Index: 1.496
• CAS DataBase Reference: Tert-Butyl2-(Trifluoromethyl)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Tert-Butyl2-(Trifluoromethyl)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate(905274-03-5)
• EPA Substance Registry System: Tert-Butyl2-(Trifluoromethyl)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate(905274-03-5)

Safety Data

• Hazardous Substances Data: 905274-03-5(Hazardous Substances Data)

Usage

General Description

Tert-Butyl2-(Trifluoromethyl)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate is a complex chemical compound consisting of a tert-butyl group, a trifluoromethyl group, a pyrrolopyrimidine ring, and a carboxylate group. It is a synthetic organic molecule with potential applications in pharmaceuticals, agrochemicals, and materials science. Tert-Butyl2-(Trifluoromethyl)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate may have biological activity and could potentially be used as a building block in the synthesis of new drugs or agrochemicals. Due to its intricate molecular structure, this chemical may have unique properties and could be of interest for further research and development in the field of organic chemistry.

InChI:InChI=1/C12H14F3N3O2/c1-11(2,3)20-10(19)18-5-7-4-16-9(12(13,14)15)17-8(7)6-18/h4H,5-6H2,1-3H3

Upstream product

• 905274-02-4 tert-butyl (3Z)-3-[(dimethylamino)methylene]-4-oxopyrrolidine-1-carboxylate 
• 354-37-0 trifluoroacetamidine 
• 157327-42-9 3-(dimethylaminomethylene)-4-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 101385-93-7 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 905274-04-6 2-(trifluoromethyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine 

Relevant articles and documents

Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: Profile of clinical candidate (2R,3S,5R)-2-(2,5-difluorophenyl)-5-[2- (methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran- 3-amine (23)

A series of novel tri-2,3,5-substituted tetrahydropyran analogs were synthesized and evaluated as inhibitors of dipeptidyl peptidase IV (DPP-4) for the treatment of type 2 diabetes. Optimization of the series provided inhibitors with good DPP-4 potency and selectivity over other peptidases (QPP, DPP8, and FAP). Compound 23, which is very potent, selective, efficacious in the diabetes PD model, and has an excellent pharmacokinetic profile, is selected as a clinical candidate.

AMINOCYCLOHEXANES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES

The present invention is directed to novel substituted aminocyclohexanes which are inhibitors of the dipeptidyl peptidase-IV enzyme (""DPP-IV inhibitors"") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.