905281-83-6Relevant articles and documents
Non-oxime pyrazole based inhibitors of B-Raf kinase
Newhouse, Bradley J.,Hansen, Joshua D.,Grina, Jonas,Welch, Mike,Topalov, George,Littman, Nicole,Callejo, Michele,Martinson, Matthew,Galbraith, Sarah,Laird, Ellen R.,Brandhuber, Barbara J.,Vigers, Guy,Morales, Tony,Woessner, Rich,Randolph, Nikole,Lyssikatos, Joseph,Olivero, Alan
, p. 3488 - 3492 (2011/06/24)
The synthesis and biological evaluation of non-oxime pyrazole based B-Raf inhibitors is reported. Several oxime replacements have been prepared and have shown excellent enzyme activity. Further optimization of fused pyrazole 2a led to compound 38, a selec