905706-71-0Relevant articles and documents
Substituted aryl pyrimidines as potent and soluble TRPV1 antagonists
Stec, Markian M.,Bo, Yunxin,Chakrabarti, Partha P.,Liao, Lillian,Ncube, Mqhele,Tamayo, Nuria,Tamir, Rami,Gavva, Narender R.,Treanor, James J.S.,Norman, Mark H.
scheme or table, p. 5118 - 5122 (2009/05/07)
Clinical candidate AMG 517 (1) is a potent antagonist toward multiple modes of activation of TRPV1; however, it suffers from poor solubility. Analogs with various substituents at the R region of 3 were prepared to improve the solubility while maintaining