905774-57-4

Basic information

• Product Name: 3-phenyl-N-(quinolin-8-yl)acrylamide
• Synonyms: 3-phenyl-N-(quinolin-8-yl)acrylamide
• CAS NO: 905774-57-4
• Molecular Weight: 274.322
• Mol File: 905774-57-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 3-phenyl-N-(quinolin-8-yl)acrylamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenyl-N-(quinolin-8-yl)acrylamide(905774-57-4)
• EPA Substance Registry System: 3-phenyl-N-(quinolin-8-yl)acrylamide(905774-57-4)

Safety Data

• Hazardous Substances Data: 905774-57-4(Hazardous Substances Data)

Upstream product

• 578-66-5 8-amino quinoline 
• 108761-28-0 (carbonic acid ethyl ester)-cinnamic acid-anhydride 
• 621-82-9 Cinnamic acid 
• 102-92-1 cinnamoyl chloride 

Downstream Products

• 1351067-19-0 (Z)-3-phenyl-N-(quinolin-8-yl)-5-(triisopropylsilyl)pent-2-en-4-ynamide 
• 103-26-4 methyl cinnamate 
• 621-82-9 Cinnamic acid 

Relevant articles and documents

Transition Metal-Free Regioselective Remote C?H Bond 2,2,2-Trifluoroethoxylation of 8-Aminoquinoline Derivatives at the C5 Position

The regioselective 2,2,2-trifluoroethoxylation at the C5 position of amides derived from the 8-aminoquinoline has been developed. In the presence of PIDA, an unprecedented and undirected transition metal-free transformation was achieved using the readily available and appealing 2,2,2-trifluoroethanol as the fluorinated source. The selective distal 2,2,2-trifluoroethoxylation of an array of amides was achieved in moderate to good yields (12 examples, up to 61 % yield). This approach provided efficient access to high-value added fluorinated quinoline derivatives, key building blocks for bulk and fine chemical industry.

Stereoselective synthesis of diazabicyclic β-lactams through intramolecular amination of unactivated C(sp3)-H bonds of carboxamides by palladium catalysis

An efficient C(sp3)-H bond activation and intramolecular amination reaction via palladium catalysis at the β-position of carboxyamides to make β-lactams was described. The investigation of the substrate scope showed that the current reaction conditions favored activation of the β-methylene group. Short sequences were developed for preparation of various diazabicyclic β-lactam compounds with this method as the key step from chiral proline and piperidine derivatives.

Cobalt-catalyzed, aminoquinoline-directed C(sp2)-H bond alkenylation by alkynes

A method for cobalt-catalyzed, aminoquinoline- and picolinamide-directed C(sp2)-H bond alkenylation by alkynes was developed. The method shows excellent functional-group tolerance and both internal and terminal alkynes are competent substrates for the coupling. The reaction employs a Co(OAc)2·4 H2O catalyst, Mn(OAc)2 co-catalyst, and oxygen (from air) as a terminal oxidant.