905845-93-4Relevant articles and documents
Synthesis, structure-activity relationship, and antimalarial activity of ureas and thioureas of 15-membered azalides
Bukvi? Kraja?i?, Mirjana,Peri?, Mihaela,Smith, Kirsten S.,Ivezi? Sch?nfeld, Zrinka,?iher, Dinko,Fajdeti?, Andrea,Kujund?i?, Nedjeljko,Sch?nfeld, Wolfgang,Landek, Goran,Padovan, Jasna,Jeli?, Dubravko,Ager, Arba,Milhous, Wilbur K.,Ellis, William,Spaventi, Radan,Ohrt, Colin
, p. 3595 - 3605 (2011/07/06)
Azithromycin, a first member of the azalide family of macrolides, while having substantial antimalarial activity, failed as a single agent for malaria prophylaxis. In this paper we present the first analogue campaign to identify more potent compounds from